Evidence map›Paper›PMID 36291289›Full record

ArticleBrain sciences2022

In Vivo Tau Burden Is Associated with Abnormal Brain Functional Connectivity in Alzheimer's Disease: A

Zizhao Ju, Zhuoyuan Li, Jiaying Lu, Fangyang Jiao, Huamei Lin, Weiqi Bao, Ming Li, Ping Wu, Yihui Guan, Qianhua Zhao and 3 more

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Zizhao JuPET Center and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai 200035, China.ORCID 0000-0002-3771-7166
Zhuoyuan LiSchool of Communication and Information Engineering, Shanghai University, Shanghai 200444, China.
Jiaying LuPET Center and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai 200035, China.
Fangyang JiaoPET Center and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai 200035, China.
Huamei LinPET Center and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai 200035, China.
Weiqi BaoPET Center and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai 200035, China.
Ming LiPET Center and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai 200035, China.
Ping WuPET Center and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai 200035, China.
Yihui GuanPET Center and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai 200035, China.
Qianhua ZhaoDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Huiwei ZhangPET Center and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai 200035, China.
Jiehui JiangInstitute of Biomedical Engineering, School of Life Science, Shanghai University, Shanghai 200444, China.ORCID 0000-0003-4948-3683
Chuantao ZuoPET Center and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai 200035, China.
Fudan University · CNShanghai University · CN

Funding

Clinical Research Plan of SHDC SHDC2020CR1038BNational Natural Science Foundation of China 81901367 82021002 81971641 81671239Research project of Shanghai Health Commission 2020YJZX0111Science and Technology Innovation 2030 Major Projects 2022ZD0211600the Open Program of Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province HYX21002
6 · The paper itself

Abstract

purpose

methods22 NC (normal control), 31 MCI and 42 AD patients who have already been scanned with

resultsHigher PLFCS and FCs in AD and MCI groups were found compared to the NC group. The PLFCS of 129 brain regions were found to be different between NC and CI groups, and 8 of them were correlated with tau SUVR, including superior parietal lobule (MCI:

conclusionsBrain functional connectivity abnormality is correlated with tau pathology in AD and MCI.

Indexed as

Alzheimer’s diseaseFlorzolotau PETfunctional connectivitymild cognitive impairment

Identifiers

PMID36291289
PMCPMC9599090
OpenAlexW4303613745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.