Evidence map›Paper›PMID 36291267›Full record

ArticleBrain sciences2022

Profiles of Caregiver-Reported Executive Function in Children with Down Syndrome.

Kaylyn Van Deusen, Mark A Prince, Anna J Esbensen, Jamie O Edgin, Emily K Schworer, Angela John Thurman, Lina R Patel, Lisa A Daunhauer, Deborah J Fidler

Abstract read
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kaylyn Van DeusenHuman Development and Family Studies, Colorado State University, Fort Collins, CO 80523, USA.
Mark A PrinceDepartment of Psychology, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-8848-0568
Anna J EsbensenDivision of Developmental and Behavioral Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0003-2649-7791
Jamie O EdginSonoran University Center for Excellence in Developmental Disabilities, University of Arizona, Tucson, AZ 85721, USA.
Emily K SchworerDivision of Developmental and Behavioral Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0002-5309-339X
Angela John ThurmanDepartment of Psychiatry, MIND Institute, University of California Davis Health, Sacramento, CA 95817, USA.
Lina R PatelDepartment of Psychiatry, University of Colorado-Anschutz Medical Campus, Aurora, CO 80045, USA.
Lisa A DaunhauerHuman Development and Family Studies, Colorado State University, Fort Collins, CO 80523, USA.
Deborah J FidlerHuman Development and Family Studies, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0001-6208-456X

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Research Project: Pathologic Significance of Maternal AutoantibodiesP50HD103526 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEONARD J. ABBEDUTO, Melissa Dawn Bauman · 2020 to 2026
$9.7M
INCLUDE19 – Evaluating outcome measures in young adults with Down syndromeR01HD093754 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI Anna J. Esbensen · 2018 to 2026
$6.2M
Executive Function Outcome Measures for Young Children with Down SyndromeR01HD099150 · NICHD · COLORADO STATE UNIVERSITY · PI DEBORAH J FIDLER · 2019 to 2026
$4.7M
Memory Measures for Clinical Trials in Down syndrome and Fragile X syndromeR01HD088409 · NICHD · UNIVERSITY OF ARIZONA · PI EDGIN, JAMIE O. · 2016 to 2020
$3.7M
Early risk for ADHD symptoms in young children with Down syndromeR21HD101000 · NICHD · COLORADO STATE UNIVERSITY · PI FIDLER, DEBORAH J · 2019 to 2020
$433k
NCATS NIH HHS UL1 TR002535NICHD NIH HHS P50 HD103526NICHD NIH HHS R01 HD088409NICHD NIH HHS R01 HD093754NICHD NIH HHS R01 HD099150NICHD NIH HHS R21 HD101000
6 · The paper itself

Abstract

Children with Down syndrome (DS) are at risk for challenges with aspects of executive function (EF). The current study explores whether heterogeneity in EF profiles can be detected within a sample of children with DS. Participants were 69 children with DS, ages 3-10 years (M = 6.23, SD = 1.91). T-scores from a caregiver-report measure of executive function were modeled using latent profile analysis, and auxiliary analyses examined the association between demographic and biomedical factors and probability of profile membership. The two-profile solution was the best fit for the sample, with a profile that involved elevated scores in working memory only ("Working Memory Only" profile; 43% of sample) and a "Multi-Domain" profile that involved elevated scores in planning, inhibition, and working memory (57%). The presence of congenital heart defects was associated with a higher probability of assignment to the Multi-Domain profile. Findings from this study contribute to the characterization of heterogeneous outcomes associated with DS.

Indexed as

Down syndromeexecutive functionlatent profile analysis

Identifiers

PMID36291267
PMCPMC9599143

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.