Evidence map›Paper›PMID 36291186›Full record

ArticleCells2022

Spatial and Temporal Diversity of Astrocyte Phenotypes in Spinocerebellar Ataxia Type 1 Mice.

Juao-Guilherme Rosa, Katherine Hamel, Carrie Sheeler, Ella Borgenheimer, Stephen Gilliat, Alyssa Soles, Ferris J Ghannoum, Kaelin Sbrocco, Hillary P Handler, Orion Rainwater and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

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  13. Contribution of Glial Cells to Polyglutamine Diseases: Observations from Patients and Mouse Models.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Juao-Guilherme RosaCvetanovic Laboratory, Department of Neuroscience, College of Medicine, University of Minnesota, 2101 6th Street SE, Minneapolis, MN 55455, USA.ORCID 0000-0002-7452-8313
Katherine HamelCvetanovic Laboratory, Department of Neuroscience, College of Medicine, University of Minnesota, 2101 6th Street SE, Minneapolis, MN 55455, USA.
Carrie SheelerCvetanovic Laboratory, Department of Neuroscience, College of Medicine, University of Minnesota, 2101 6th Street SE, Minneapolis, MN 55455, USA.
Ella BorgenheimerCvetanovic Laboratory, Department of Neuroscience, College of Medicine, University of Minnesota, 2101 6th Street SE, Minneapolis, MN 55455, USA.
Stephen GilliatCvetanovic Laboratory, Department of Neuroscience, College of Medicine, University of Minnesota, 2101 6th Street SE, Minneapolis, MN 55455, USA.ORCID 0000-0002-8952-6417
Alyssa SolesCvetanovic Laboratory, Department of Neuroscience, College of Medicine, University of Minnesota, 2101 6th Street SE, Minneapolis, MN 55455, USA.ORCID 0000-0003-1164-973X
Ferris J GhannoumCvetanovic Laboratory, Department of Neuroscience, College of Medicine, University of Minnesota, 2101 6th Street SE, Minneapolis, MN 55455, USA.
Kaelin SbroccoCvetanovic Laboratory, Department of Neuroscience, College of Medicine, University of Minnesota, 2101 6th Street SE, Minneapolis, MN 55455, USA.
Hillary P HandlerCvetanovic Laboratory, Department of Neuroscience, College of Medicine, University of Minnesota, 2101 6th Street SE, Minneapolis, MN 55455, USA.ORCID 0000-0001-5757-4548
Orion RainwaterInstitute for Translational Neuroscience, College of Medicine, University of Minnesota, 2101 6th Street SE, Minneapolis, MN 55455, USA.
Ryan KangCvetanovic Laboratory, Department of Neuroscience, College of Medicine, University of Minnesota, 2101 6th Street SE, Minneapolis, MN 55455, USA.ORCID 0000-0002-7573-5453
Marija CvetanovicCvetanovic Laboratory, Department of Neuroscience, College of Medicine, University of Minnesota, 2101 6th Street SE, Minneapolis, MN 55455, USA.
University of Minnesota · USBoston University · US

Funding

Etiology of cognitive decline in Spinocerebellar ataxia type 1R01NS109077 · NINDS · UNIVERSITY OF MINNESOTA · PI Marija Cvetanovic, TIMOTHY J EBNER · 2020 to 2026
$2.4M
NINDS NIH HHS R01 NS109077
6 · The paper itself

Abstract

While astrocyte heterogeneity is an important feature of the healthy brain, less is understood about spatiotemporal heterogeneity of astrocytes in brain disease. Spinocerebellar ataxia type 1 (SCA1) is a progressive neurodegenerative disease caused by a CAG repeat expansion in the gene

Indexed as

AstrocytesSpinocerebellar AtaxiasAnimalsAtaxin-1CerebellumMicePhenotypeAtaxin-1astrocytesbrain regiongene expressionmicrogliamorphologyneurodegenerationSCA1

Identifiers

PMID36291186
PMCPMC9599982
OpenAlexW4307122359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.