Evidence map›Paper›PMID 36291125›Full record

ArticleCells2022

An Alzheimer's Disease Patient-Derived Olfactory Stem Cell Model Identifies Gene Expression Changes Associated with Cognition.

Laura M Rantanen, Maina Bitar, Riikka Lampinen, Romal Stewart, Hazel Quek, Lotta E Oikari, Carla Cunί-Lόpez, Ratneswary Sutharsan, Gayathri Thillaiyampalam, Jamila Iqbal and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Altered PLCβ/IPBiomedicines · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Unraveling the Link between Olfactory Deficits and Neuropsychiatric Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 2 countries.

Laura M RantanenMental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.ORCID 0000-0002-7162-1459
Maina BitarMental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Riikka LampinenA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland.ORCID 0000-0002-1485-5179
Romal StewartMental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Hazel QuekMental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.ORCID 0000-0001-5597-5372
Lotta E OikariMental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Carla Cunί-LόpezMental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Ratneswary SutharsanMental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Gayathri ThillaiyampalamGriffith Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia.
Jamila IqbalGriffith Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia.
Daniel RussellGriffith Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia.ORCID 0000-0003-4719-4706
Elina PenttiläDepartment of Otorhinolaryngology, University of Eastern Finland, Kuopio University Hospital, 70210 Kuopio, Finland.
Heikki LöppönenDepartment of Otorhinolaryngology, University of Eastern Finland, Kuopio University Hospital, 70210 Kuopio, Finland.
Juha-Matti LehtolaBrain Research Unit, Department of Neurology, School of Medicine, University of Eastern Finland, 70210 Kuopio, Finland.ORCID 0000-0002-1018-0186
Toni SaariBrain Research Unit, Department of Neurology, School of Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
Sanna HannonenBrain Research Unit, Department of Neurology, School of Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
Anne M KoivistoBrain Research Unit, Department of Neurology, School of Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
Larisa M HauptGenomics Research Centre, Centre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, QLD 4059, Australia.ORCID 0000-0002-7735-8110
Alan Mackay-SimGriffith Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia.ORCID 0000-0003-4446-5371
Alexandre S CristinoGriffith Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia.ORCID 0000-0002-3468-0919
Katja M KanninenA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland.ORCID 0000-0002-6717-8589
Anthony R WhiteMental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.ORCID 0000-0003-1802-9891
University of Eastern Finland · FIQIMR Berghofer Medical Research Institute · AUGriffith University · AUQueensland University of Technology · AUThe University of Queensland · AUUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An early symptom of Alzheimer's disease (AD) is an impaired sense of smell, for which the molecular basis remains elusive. Here, we generated human olfactory neurosphere-derived (ONS) cells from people with AD and mild cognitive impairment (MCI), and performed global RNA sequencing to determine gene expression changes. ONS cells expressed markers of neuroglial differentiation, providing a unique cellular model to explore changes of early AD-associated pathways. Our transcriptomics data from ONS cells revealed differentially expressed genes (DEGs) associated with cognitive processes in AD cells compared to MCI, or matched healthy controls (HC). A-Kinase Anchoring Protein 6 (

Indexed as

Alzheimer DiseaseCognitionGene ExpressionOlfactory MucosaStem CellsA Kinase Anchor ProteinsCells, CulturedHumansA Kinase Anchor ProteinsagingAKAP6Alzheimer’s diseasecognitionmild cognitive impairmentolfactory neurosphere-derived cellspatient-derived olfactory mucosaRNA Sequencing

Identifiers

PMID36291125
PMCPMC9601087
OpenAlexW4306403571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.