ReviewCells2022
Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications.
Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 6 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Pharmacological thromboprophylaxis in hospitalized patients with acute infectious diseases: a meta-analysis.European journal of clinical pharmacology · 2026Pooled it
- Safety and Efficacy of Direct Oral Anticoagulants Versus Vitamin K Antagonists for Cerebrovascular Ischemic Outcomes in Non-Valvular Atrial Fibrillation: A Systematic Review and Meta-Analysis.Clinical cardiology · 2026Pooled it
- Cutting Through the Clot: Rethinking Venous Thromboembolism Prophylaxis in Plastic Surgery with Aspirin, Direct Oral Anticoagulants, and Low Molecular Weight Heparin.Aesthetic plastic surgery · 2026Pooled it
- Safety and efficacy of routine anticoagulation after primary PCI in STEMI: a systematic review and meta-analysis.Journal of thrombosis and thrombolysis · 2025Pooled it
- Bibliometric analysis of postoperative deep vein thrombosis in total hip arthroplasty using CiteSpace.Frontiers in surgery · 2025Pooled it
- Efficacy and safety of anticoagulants on venous thromboembolism: a systematic review and network meta-analysis of randomized controlled trials.Frontiers in pharmacology · 2024Pooled it
- Effect of the coughing technique during subcutaneous heparin injection on pain severity and individual satisfaction.Revista latino-americana de enfermagem · 2023Trial
- Anticoagulants, Their Laboratory Monitoring, and Reversal.Hematology reports · 2026Review
- Complementary targeted constructs factor XI/XIa inhibition.Blood advances · 2026Article
- Pharmacokinetic Variability of Direct Oral Anticoagulants and Calcium Channel Blockers: A Comparative Analysis of Exposure Data from Clinical Studies.Pharmaceutics · 2026Article
- Forensic LC-MS/MS Monitoring of Anticoagulant Rodenticide Poisoning in Cats Over a Half-Decade.Veterinary medicine and science · 2026Article
- Patterns of deprescribing after an emergency department visit due to adverse drug events among concomitant users of antithrombotics and other medications.medRxiv : the preprint server for health sciences · 2026Article
- Pharmacogenomics of Rivaroxaban: Association ofPharmaceutics · 2026Article
- Review
- Antithrombotic therapy and risk of intracranial hemorrhage in patients with cerebral cavernous malformations: a multicenter propensity-matched cohort study.Journal of neurology · 2026Article
- Subdural and epidural hematoma following lumbar puncture in patients on anticoagulants or antiplatelets: A retrospective propensity score-matched registry study.Acta neurologica Belgica · 2026Article
- Screening for Potential Drug-Drug Interactions in Patients Receiving Anticoagulant Therapy: A Comparison of Three Drug Interaction Databases for Consistency in Severity Rating, Evidence Classification, and Clinical Management.Medicina (Kaunas, Lithuania) · 2026Article
- Heparin microarray-based specific interaction assay of marine sulfated polysaccharides with antithrombin Ⅲ.Communications chemistry · 2026Article
- Association of lipid-lowering drugs with venous thromboembolism outcomes: a phenome-wide association study and a drug-target Mendelian randomization study.Journal of thrombosis and thrombolysis · 2026Article
- Deep vein thrombosis incidence after sequential Low-molecular-weight heparin and Rivaroxaban versus no prophylaxis in posterior cruciate ligament avulsion fractures.Scientific reports · 2026Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anticoagulant drugs antagonize coagulation and are used to prevent or cure (recurrent) venous thromboembolism (VTE). Drugs to prevent clotting have been used for more than a century, and, nowadays, physicians possess a broad panel of multiple anticoagulants to meet the individual needs of a patient. Within this review, we aimed to revise the history of the different anticoagulants that are currently prescribed in the clinic. In addition, we compared their pharmacological properties, medical indications, and the difficulties in implementing new anticoagulants in vulnerable patient populations. Since the introduction of unfractionated heparin in the 1930s, major advances in the mechanistic understanding and the medical use of anticoagulants have allowed for significant improvements to treat VTE patients. However, a new generation of anticoagulants is currently being tested in clinical trials, with the goal of further optimizing medical care.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.