Evidence map›Paper›PMID 36291054›Full record

ArticleCells2022

Retinoic Acid Receptor Alpha (RARα) in Macrophages Protects from Diet-Induced Atherosclerosis in Mice.

Fathima N Cassim Bawa, Raja Gopoju, Yanyong Xu, Shuwei Hu, Yingdong Zhu, Shaoru Chen, Kavita Jadhav, Yanqiao Zhang

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Role ofCurrent medicinal chemistry · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Retinoic Acid Signaling in Fatty Liver Disease.Liver research (Beijing, China) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Fathima N Cassim BawaDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Raja GopojuDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Yanyong XuDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Shuwei HuDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Yingdong ZhuDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Shaoru ChenDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Kavita JadhavDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Yanqiao ZhangDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA.ORCID 0000-0002-1886-7775
Northeast Ohio Medical University · USKent State University · US

Funding

Mechanisms Underlying the Pathogenesis of Non-alcoholic Fatty Liver DiseaseR01DK102619 · NIDDK · UNIVERSITY OF ARIZONA · PI Yanqiao Zhang · 2015 to 2026
$4.0M
Role of Hepatocyte ATF3 in NAFLDR01DK118941 · NIDDK · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ZHANG, YANQIAO · 2018 to 2021
$1.8M
NIDDK NIH HHS R01 DK102619
6 · The paper itself

Abstract

Retinoic acid signaling plays an important role in regulating lipid metabolism and inflammation. However, the role of retinoic acid receptor alpha (RARα) in atherosclerosis remains to be determined. In the current study, we investigated the role of macrophage RARα in the development of atherosclerosis. Macrophages isolated from myeloid-specific

Indexed as

AtherosclerosisCholesterolDiet, WesternMacrophagesRetinoic Acid Receptor alphaAnimalsATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1InflammationMiceMice, KnockoutTretinoinAbca1 protein, mouseABCG1 protein, mouseATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1CholesterolRara protein, mouseRetinoic Acid Receptor alphaTretinoinall-trans retinoic acidatherosclerosischolesterol effluxmacrophagesretinoic acid receptor alpha

Identifiers

PMID36291054
PMCPMC9600071
OpenAlexW4304185595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.