Evidence map›Paper›PMID 36290992›Full record

ArticleBiosensors2022

Systematic Screening of Trigger Moieties for Designing Formaldehyde Fluorescent Probes and Application in Live Cell Imaging.

Yin Jiang, Shumei Huang, Minghui Liu, Zejun Li, Weimin Xiao, Huatang Zhang, Liu Yang, Hongyan Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Yin JiangSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
Shumei HuangSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
Minghui LiuSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
Zejun LiSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
Weimin XiaoShenzhen Academy of Metrology & Quality Inspection, Shenzhen 518110, China.
Huatang ZhangSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
Liu YangCollege of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
Hongyan SunDepartment of Chemistry and Center of Super-Diamond and Advanced Films (COSDAF), City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong 999077, China.
Guangdong University of Technology · CNCentral South University · CNCity University of Hong Kong · HKShenzhen Academy of Metrology and Quality Inspection · CN

Funding

Guangdong Basic and Applied Basic Research Foundation 2020A1515011463National Natural Science Foundation of China 22078067, 32122003 and 21807014the Pearl River Talent Plan of Guangdong Province 2017GC010596the Science Technology and Innovation Committee of Shenzhen Municipality JCYJ20180507181654823
6 · The paper itself

Abstract

Formaldehyde (FA) is involved in multiple physiological regulatory processes and plays a crucial role in memory storage. Meanwhile, FA has a notorious reputation as a toxic compound, and it will cause a variety of diseases if its level is unbalanced in the human body. To date, there have been numerous fluorescent probes for FA imaging reported. Among them, the probes based on the 2-aza-Cope rearrangement have attracted the most attention, and their applications in cell imaging have been greatly expanded. Herein, we screened the various trigger moieties of FA fluorescent probes based on the mechanism of 2-aza-Cope rearrangement. FA-2, in which a fluorophore is connected to a 4-nitrobenzylamine group and an allyl group, demonstrated the highest sensitivity, selectivity, and reaction kinetics. Furthermore, FA-Lyso, derived from FA-2, has been successfully designed and applied to monitor exogenous and endogenous FA fluctuations in lysosomes of living cells.

Indexed as

Fluorescent DyesFormaldehydeHumansFluorescent DyesFormaldehyde2−aza−Cope rearrangementcell imagingfluorescent probeformaldehyde

Identifiers

PMID36290992
PMCPMC9599387
OpenAlexW4304127913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.