Evidence map›Paper›PMID 36290977›Full record

ArticleBiosensors2022

An Optimization Framework for Silicon Photonic Evanescent-Field Biosensors Using Sub-Wavelength Gratings.

Lauren S Puumala, Samantha M Grist, Kithmin Wickremasinghe, Mohammed A Al-Qadasi, Sheri Jahan Chowdhury, Yifei Liu, Matthew Mitchell, Lukas Chrostowski, Sudip Shekhar, Karen C Cheung

Abstract read
In one paragraph

Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lauren S PuumalaSchool of Biomedical Engineering, University of British Columbia, 251-2222 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.
Samantha M GristSchool of Biomedical Engineering, University of British Columbia, 251-2222 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.
Kithmin WickremasingheDepartment of Electrical and Computer Engineering, University of British Columbia, 5500-2332 Main Mall, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0003-1822-649X
Mohammed A Al-QadasiDepartment of Electrical and Computer Engineering, University of British Columbia, 5500-2332 Main Mall, Vancouver, BC V6T 1Z4, Canada.
Sheri Jahan ChowdhuryDepartment of Electrical and Computer Engineering, University of British Columbia, 5500-2332 Main Mall, Vancouver, BC V6T 1Z4, Canada.
Yifei LiuDepartment of Electrical and Computer Engineering, University of British Columbia, 5500-2332 Main Mall, Vancouver, BC V6T 1Z4, Canada.
Matthew MitchellDream Photonics Inc., Vancouver, BC V6T 0A7, Canada.ORCID 0000-0002-9949-3858
Lukas ChrostowskiDream Photonics Inc., Vancouver, BC V6T 0A7, Canada.
Sudip ShekharDream Photonics Inc., Vancouver, BC V6T 0A7, Canada.
Karen C CheungSchool of Biomedical Engineering, University of British Columbia, 251-2222 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.

Funding

Canada's Digital Technology Supercluster Supercluster
6 · The paper itself

Abstract

Silicon photonic (SiP) evanescent-field biosensors aim to combine the information-rich readouts offered by lab-scale diagnostics, at a significantly lower cost, and with the portability and rapid time to result offered by paper-based assays. While SiP biosensors fabricated with conventional strip waveguides can offer good sensitivity for label-free detection in some applications, there is still opportunity for improvement. Efforts have been made to design higher-sensitivity SiP sensors with alternative waveguide geometries, including sub-wavelength gratings (SWGs). However, SWG-based devices are fragile and prone to damage, limiting their suitability for scalable and portable sensing. Here, we investigate SiP microring resonator sensors designed with SWG waveguides that contain a "fishbone" and highlight the improved robustness offered by this design. We present a framework for optimizing fishbone-style SWG waveguide geometries based on numerical simulations, then experimentally measure the performance of ring resonator sensors fabricated with the optimized waveguides, targeting operation in the O-band and C-band. For the O-band and C-band devices, we report bulk sensitivities up to 349 nm/RIU and 438 nm/RIU, respectively, and intrinsic limits of detection as low as 5.1 × 10

Indexed as

Biosensing TechniquesSiliconOptics and PhotonicsPhotonsSiliconbridged SWG waveguideevanescent field biosensorfishbone sub-wavelength grating waveguidemicrofluidicsring resonatorsilicon photonicsSOI biosensorsub-wavelength grating waveguideSWG-assist waveguide

Identifiers

PMID36290977
PMCPMC9599562

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.