ArticleCurrent oncology (Toronto, Ont.)2022
Papillary Tumor of the Pineal Region Rare Pediatric CNS Tumor Case Series Treated in King Fahad Medical City (KFMC).
Article in Current oncology (Toronto, Ont.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Papillary Tumor of the Pineal Region Identified by DNA Methylation Leads to the Incidental Finding of Germline MutationCurrent oncology (Toronto, Ont.) · 2025Pooled it
- Papillary Tumors of the Pineal Region (PTPR) in Pediatric Population: A Case Report and Literature Review.Asia-Pacific journal of clinical oncology · 2026Review
- Fractionated Gamma Knife Radiation for Papillary Tumor of the Pineal Region: A Case Report and Literature Review.Clinical case reports · 2026Article
- Pineal Gland Parenchyma Tumors.Advances and technical standards in neurosurgery · 2026Review
- Two illustrative cases of papillary tumor of the pineal region: Clinical presentation, management, and outcomes.Surgical neurology international · 2025Article
- Determination of Optimal Treatment Plan for Papillary Tumor of the Pineal Region: Case Series With Literature Review.Brain tumor research and treatment · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical behaviors, prognosis, and appropriate treatments of papillary tumors of the pineal region (PTPR) are not fully defined due to the rarity of these tumors. At diagnosis, PTPR may present with clinical symptoms, including headache with obstructive hydrocephalus, diplopia, vomiting, and lethargy, as well as neurological signs, including Argyll Robertson pupils and Parinaud's syndrome due to compression of the dorsal midbrain, specifically the periaqueductal region with horizontal nystagmus. Radiological assessment of pineal region lesions is challenging, with a wide range of potential differential diagnoses. PTPR typically presents as a heterogeneous, well-circumscribed mass in the pineal region, which might contain cystic areas, calcifications, hemorrhages, or protein accumulations. Here, we report three female pediatric patients with PTPR treated in King Fahad Medical City (KFMC) in Saudi Arabia. Histological and immunohistochemical diagnosis was confirmed by analysis of genome-wide DNA methylation profiles. This case series expands on the available reports on the clinical presentations of PTPR and provides important information on the responses to different treatment modalities.
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