Evidence map›Paper›PMID 36290831›Full record

ArticleCurrent oncology (Toronto, Ont.)2022

Quantitative Analysis of SARS-CoV-2 Antibody Levels in Cancer Patients Post Three Doses of Immunization and Prior to Breakthrough COVID-19 Infections.

Kathryn Macrae, Jorge Martinez-Cajas, Kristin Bessai, Abulhameed Abdulhamed, Yanping Gong

Open access · goldAbstract read
In one paragraph

Article in Current oncology (Toronto, Ont.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Anti-SARS-CoV-2 Antibody Levels in a Cohort of Health Care Workers Before and After the Omicron Wave in Canada.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kathryn MacraeDepartment of Pathology and Molecular Medicine, Kingston Health Sciences Centre and Queen's University, Kingston, ON K7L 3N6, Canada.ORCID 0000-0001-8297-7787
Jorge Martinez-CajasDivision of Infectious Diseases, Kingston Health Sciences Centre and Queen's University, Kingston, ON K7L 3N6, Canada.
Kristin BessaiDepartment of Pathology and Molecular Medicine, Kingston Health Sciences Centre and Queen's University, Kingston, ON K7L 3N6, Canada.
Abulhameed AbdulhamedDepartment of Pathology and Molecular Medicine, Kingston Health Sciences Centre and Queen's University, Kingston, ON K7L 3N6, Canada.ORCID 0000-0001-9649-2385
Yanping GongDepartment of Pathology and Molecular Medicine, Kingston Health Sciences Centre and Queen's University, Kingston, ON K7L 3N6, Canada.
Queen's University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: COVID-19 vaccine effectiveness should be carefully evaluated and explicitly defined. To our knowledge, this is the first report to quantitatively evaluate humoral responses post 3 doses of SARS-CoV-2 immunization and prior to breakthrough COVID-19 infection in Canadian cancer patients. (2) Methods: In a prospective cohort study, we enrolled 185 cancer participants post COVID-19 vaccination in Kingston, Ontario, Canada. IgG antibodies against the SARS-CoV-2 spike receptor-binding domain were quantified by immunoassay post three doses of immunization. With the COVID-19 rapid antigen test and polymerase chain reaction (PCR), 16 breakthrough infections were identified. Results: Following SARS-CoV-2 vaccination (including BNT162b2, AZD1222, and mRNA-1273), the mean serum anti-spike protein antibody level was 197.2 BAU/mL (binding antibody unit, SD ± 393.9), 1335.9 BAU/mL (±3337.8), and 3164.8 BAU/mL (±6500.9) post the first, second, and third dose of vaccination. Observed differences were significant (

Indexed as

COVID-19NeoplasmsAntibodies, ViralBNT162 VaccineChAdOx1 nCoV-19COVID-19 VaccinesHumansImmunizationImmunoglobulin GOntarioProspective StudiesSARS-CoV-2VaccinationAntibodies, ViralBNT162 VaccineChAdOx1 nCoV-19COVID-19 VaccinesImmunoglobulin Gcancer patientsoncologySARS-CoV-2vaccine

Identifiers

PMID36290831
PMCPMC9599995
OpenAlexW4297464605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.