Evidence map›Paper›PMID 36290621›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Red Raspberry Seed Oil Low Energy Nanoemulsions: Influence of Surfactants, Antioxidants, and Temperature on Oxidative Stability.

Ana Gledovic, Aleksandra Janosevic-Lezaic, Slobodanka Tamburic, Snezana Savic

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Uncovering the efficacy of a natural homemade sunscreen in protection from ultraviolet radiation.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Ana GledovicDepartment of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, 11121 Belgrade, Serbia.ORCID 0000-0003-2697-8800
Aleksandra Janosevic-LezaicDepartment of Physical Chemistry and Instrumental Methods, Faculty of Pharmacy, University of Belgrade, 11121 Belgrade, Serbia.ORCID 0000-0003-4343-0572
Slobodanka TamburicCosmetic Science Research Group, London College of Fashion, University of the Arts London, London WC1V 7EY, UK.
Snezana SavicDepartment of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, 11121 Belgrade, Serbia.ORCID 0000-0002-6236-9730
University of Belgrade · RSUniversity of the Arts London · GB

Funding

Ministry of Education, Science and Technological Development, Republic of Serbia Grant Agreement with University of Belgrade - Faculty of Pharmacy No: 451-03-68/2022-14/200161).
6 · The paper itself

Abstract

The aim of this study was to assess and improve the oxidative stability of red raspberry seed oil−RO, a potential topical ingredient derived from food industry by-products, on its own and when incorporated in low energy nanoemulsion (NE). The RO’s oxidative stability was assessed at 5, 25, and 40 °C during one month of storage and expressed in: peroxide value, p-anisidine, and thiobarbituric reactive substances—TBARS value, while for NEs, lipid hydroperoxides and TBARS values were monitored. Both synthetic (butylated hydroxytoluene—BHT and ethylenediaminetetraacetic acid—EDTA), and natural (oregano essential oil—ORE and oak fruit extract—OAK) antioxidants were used. Pure RO and RO with BHT or ORE were stable at 5 °C and 25 °C, but at 40 °C BHT showed only moderate protection, while ORE was prooxidant. NEs prepared with new biodegradable polyglycerol esters-based surfactants, with droplet sizes of < 50 nm and narrow size distribution, showed improved physicochemical stability at room temperature, and especially at 40 °C, compared to NEs with polysorbate 80, which required the addition of antioxidants to preserve their stability. Natural antioxidants ORE and OAK were compatible with all NEs; therefore, their use is proposed as an effective alternative to synthetic antioxidants.

Indexed as

nanoemulsificationnaturaloak extractoregano oilpolyglycerol esterpolysorbate 80

Identifiers

PMID36290621
PMCPMC9598911
OpenAlexW4297146585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.