Evidence map›Paper›PMID 36290615›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Luteolin-Induced Activation of Mitochondrial BK

Rafał P Kampa, Lorenzo Flori, Aleksandra Sęk, Jacopo Spezzini, Simone Brogi, Adam Szewczyk, Vincenzo Calderone, Piotr Bednarczyk, Lara Testai

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Luteolin Alleviates Axitinib-Induced Cardiomyocyte Apoptosis in Mice.Journal of biochemical and molecular toxicology · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Research Progress of Flavonoids Regulating Endothelial Function.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  8. Flavonoids as Modulators of Potassium Channels.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Rafał P KampaLaboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology PAS, 02-093 Warsaw, Poland.ORCID 0000-0002-8913-6881
Lorenzo FloriDepartment of Pharmacology, Faculty of Pharmacy, University of Pisa, 6 via Bonanno Pisano, 56120 Pisa, Italy.ORCID 0000-0001-7899-0954
Aleksandra SękLaboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology PAS, 02-093 Warsaw, Poland.ORCID 0000-0002-2686-5657
Jacopo SpezziniDepartment of Pharmacology, Faculty of Pharmacy, University of Pisa, 6 via Bonanno Pisano, 56120 Pisa, Italy.ORCID 0000-0002-7308-372X
Simone BrogiDepartment of Pharmacology, Faculty of Pharmacy, University of Pisa, 6 via Bonanno Pisano, 56120 Pisa, Italy.ORCID 0000-0001-9375-6242
Adam SzewczykLaboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology PAS, 02-093 Warsaw, Poland.ORCID 0000-0001-5519-260X
Vincenzo CalderoneDepartment of Pharmacology, Faculty of Pharmacy, University of Pisa, 6 via Bonanno Pisano, 56120 Pisa, Italy.
Piotr BednarczykDepartment of Physics and Biophysics, Institute of Biology, Warsaw University of Life Sciences-SGGW (WULS-SGGW), 159 Nowoursynowska St., 02-776 Warsaw, Poland.ORCID 0000-0002-7125-0715
Lara TestaiDepartment of Pharmacology, Faculty of Pharmacy, University of Pisa, 6 via Bonanno Pisano, 56120 Pisa, Italy.ORCID 0000-0003-2431-6248
University of Pisa · ITInstytut Biologii Doświadczalnej im. Marcelego Nenckiego · PLWarsaw University of Life Sciences · PL

Funding

ETHIUDA 2020/36/T/NZ1/00116National Science Center of Poland 2016/21/B/NZ1/02769
6 · The paper itself

Abstract

Luteolin (LUT) is a well-known flavonoid that exhibits a number of beneficial properties. Among these, it shows cardioprotective effects, as confirmed by numerous studies. However, its effect on mitochondrial potassium channels, the activation of which is related to cytoprotection, as well as on heart ischemia/reperfusion (I/R) damage prevention, has not yet been investigated. The large conductance calcium-regulated potassium channel (mitoBK

Indexed as

acute myocardial infarctionapoptosiscardioprotectionluteolinmitoBKCa channel activationnecrosis

Identifiers

PMID36290615
PMCPMC9598376
OpenAlexW4297151992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.