ArticleAntioxidants (Basel, Switzerland)2022
Artemisinin Targets Transcription Factor PDR1 and Impairs
Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- EndophyticPlants (Basel, Switzerland) · 2025Article
- Artemisinin effects on Gastrointestinal tissues in Candida albicans-infected mice: histological and functional evaluation.Journal of molecular histology · 2025Article
- Artesunate Treats Aspergillus fumigatus Keratitis by Inhibiting Fungal Activity and Activating Autophagy Pathway to Reduce Corneal Inflammation.Investigative ophthalmology & visual science · 2025Article
- The molecular mechanism of traditional Chinese medicine in the treatment of oropharyngeal candidiasis (OPC).Journal of oral microbiology · 2025Review
- Artemisinin May Disrupt Hyphae Formation by Suppressing Biofilm-Related Genes ofAntibiotics (Basel, Switzerland) · 2024Article
- Unexpected Inhibitory Effect of Octenidine Dihydrochloride onAntibiotics (Basel, Switzerland) · 2023Article
- Redefining pleiotropic drug resistance in a pathogenic yeast: Pdr1 functions as a sensor of cellular stresses inmSphere · 2023Article
- Antimicrobial Susceptibility Testing for ThreeMicrobiology spectrum · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A limited number of antifungal drugs, the side-effect of clinical drugs and the emergence of resistance create an urgent need for new antifungal treatment agents. High-throughput drug screening and in-depth drug action mechanism analyzation are needed to address this problem. In this study, we identified that artemisinin and its derivatives possessed antifungal activity through a high-throughput screening of the FDA-approved drug library. Subsequently, drug-resistant strains construction, a molecular dynamics simulation and a transcription level analysis were used to investigate artemisinin's action mechanism in
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Registered trials
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