Evidence map›Paper›PMID 36290571›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Structural Characterization of Peripolin and Study of Antioxidant Activity of HMG Flavonoids from Bergamot Fruit.

Lucia Bartella, Fabio Mazzotti, Ines Rosita Talarico, Giuseppina De Luca, Ilaria Santoro, Mario Prejanò, Costanza Riccioni, Tiziana Marino, Leonardo Di Donna

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lucia BartellaQUASIORA Laboratory, AGRINFRA Research Net, Università Della Calabria, Via P. Bucci Cubo 12/D, I-87036 Arcavacata di Rende, CS, Italy.
Fabio MazzottiQUASIORA Laboratory, AGRINFRA Research Net, Università Della Calabria, Via P. Bucci Cubo 12/D, I-87036 Arcavacata di Rende, CS, Italy.
Ines Rosita TalaricoQUASIORA Laboratory, AGRINFRA Research Net, Università Della Calabria, Via P. Bucci Cubo 12/D, I-87036 Arcavacata di Rende, CS, Italy.
Giuseppina De LucaDipartimento di Chimica e Tecnologie Chimiche, Università Della Calabria, Via P. Bucci, Cubo 12/D, I-87030 Rende, CS, Italy.ORCID 0000-0002-7509-2232
Ilaria SantoroQUASIORA Laboratory, AGRINFRA Research Net, Università Della Calabria, Via P. Bucci Cubo 12/D, I-87036 Arcavacata di Rende, CS, Italy.
Mario PrejanòDipartimento di Chimica e Tecnologie Chimiche, Università Della Calabria, Via P. Bucci, Cubo 12/D, I-87030 Rende, CS, Italy.ORCID 0000-0002-9140-6246
Costanza RiccioniEsserre Pharma SrL R&D Department, Via Flaminia Nuova 260, I-00191 Roma, RM, Italy.ORCID 0000-0003-1527-8024
Tiziana MarinoDipartimento di Chimica e Tecnologie Chimiche, Università Della Calabria, Via P. Bucci, Cubo 12/D, I-87030 Rende, CS, Italy.ORCID 0000-0003-2386-9078
Leonardo Di DonnaQUASIORA Laboratory, AGRINFRA Research Net, Università Della Calabria, Via P. Bucci Cubo 12/D, I-87036 Arcavacata di Rende, CS, Italy.

Funding

AgrInfra Calabria POR FESR-FSE Calabria 2014/2020, Action 1.5.1 grant U9140500504Italian Ministry of Foreign Affairs and International Cooperation, H28D20000370001PSR Calabria 2014/2020 - MISURA 16 INTERVENTO 16.02.01 "FARMABERG" grant J36G2000043005
6 · The paper itself

Abstract

The structural characterization of a new flavonoid from bergamot fruit (Citrus bergamia Risso) carrying the 3-hydroxy-3-methyl glutaryl (HMG) ester moiety has been accomplished, and its antioxidant ability was tested from a chemical point of view. The peculiarity of the new molecule, named peripolin, relies on the presence of the HMG chemical group linked to the sugar portion of neoeriocitrin; the structure was elucidated using both high-resolution mass spectrometry and nuclear magnetic resonance experiments performed on the purified molecule extracted from the fruit. The antioxidant ability of the new molecule was tested by classical chemical approaches, such as DPPH, ABTS and FRAP assays, and from a theoretical point of view.

Indexed as

antioxidant activitybergamotcitrus bergamiahigh-resolution mass spectrometryHMG flavonoidsperipolinstatinstructure elucidation

Identifiers

PMID36290571
PMCPMC9598738

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.