Evidence map›Paper›PMID 36290569›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Novel Cinnamaldehyde Derivatives Inhibit Peripheral Nerve Degeneration by Targeting Schwann Cells.

Yoo Lim Chun, Ki-Hoon Park, Badvel Pallavi, Won-Joon Eom, Chan Park, Youngbuhm Huh, Yeonjoo Lee, Jimin Lee, Sang Hoon Kim, Seung Geun Yeo and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Cinnamon and Derivatives as Modulators of Toll-like Receptors.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Article
  4. Targeting the Hippo pathway in Schwann cells ameliorates peripheral nerve degeneration via a polypharmacological mechanism.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Article
  5. Diabetic neuropathy: A NRF2 disease?Journal of diabetes · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Yoo Lim ChunDepartment of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea.
Ki-Hoon ParkDepartment of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea.
Badvel PallaviThe Research Institute of Natural Science, Department of Chemistry Education, Gyeongsang National University, Gyeongnam, Jinju 52828, Korea.
Won-Joon EomDepartment of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea.
Chan ParkDepartment of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea.
Youngbuhm HuhDepartment of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea.
Yeonjoo LeeThe Research Institute of Natural Science, Department of Chemistry Education, Gyeongsang National University, Gyeongnam, Jinju 52828, Korea.
Jimin LeeDepartment of Anatomy and Cell Biology, College of Medicine, Dong-A University, Seo-gu, Busan 49201, Korea.
Sang Hoon KimDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea.ORCID 0000-0001-5045-5060
Seung Geun YeoDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea.ORCID 0000-0001-8021-1024
Hyung-Joo ChungDepartment of Anesthesiology and Pain Medicine, College of Medicine, Kosin University, Seo-gu, Busan 49267, Korea.
Byeong-Seon KimThe Research Institute of Natural Science, Department of Chemistry Education, Gyeongsang National University, Gyeongnam, Jinju 52828, Korea.
Na Young JeongDepartment of Anatomy and Cell Biology, College of Medicine, Dong-A University, Seo-gu, Busan 49201, Korea.
Junyang JungDepartment of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea.ORCID 0000-0003-3946-5406
Kyung Hee University · KRGyeongsang National University · KRDong-A University · KRKosin University · KR

Funding

National Research Foundation of Korea (NRF) 2018R1D1A1B07040282National Research Foundation of Korea (NRF) 2020R1C1C1013785National Research Foundation of Korea (NRF) 2021R1A2C1004133National Research Foundation of Korea (NRF) 2021R1A2C1004184National Research Foundation of Korea (NRF) 2022R1A4A5034331National Research Foundation of Korea (NRF) 2022R1I1A1A01053751
6 · The paper itself

Abstract

Peripheral nerve degeneration (PND) is a preparative process for peripheral nerve regeneration and is regulated by Schwann cells, a unique glial cell in the peripheral nervous system. Dysregulated PND induces irreversible peripheral neurodegenerative diseases (e.g., diabetic peripheral neuropathy). To develop novel synthetic drugs for these diseases, we synthesized a set of new cinnamaldehyde (CAH) derivatives and evaluated their activities in vitro, ex vivo, and in vivo. The 12 CAH derivatives had phenyl or naphthyl groups with different substitution patterns on either side of the

Indexed as

cinnamaldehydeperipheral nerve degenerationSchwann cellsTg(mbp:eGFP) zebrafish modelTRPA1

Identifiers

PMID36290569
PMCPMC9598575
OpenAlexW4297906775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.