Evidence map›Paper›PMID 36290454›Full record

ArticleBioengineering (Basel, Switzerland)2022

Comparative Evaluation of Various Extraction Techniques for Secondary Metabolites from

Sara Yasien, Muhammad Muntazir Iqbal, Mohsin Javed, Maha Abdallah Alnuwaiser, Shahid Iqbal, Qaiser Mahmood, Eslam B Elkaeed, Ayed A Dera, Hamad Alrbyawi, Rami Adel Pashameah and 2 more

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Highly Efficient Regeneration ofPlants (Basel, Switzerland) · 2025
    Article
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  3. Article
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  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sara YasienCollege of Pharmacy, University of the Punjab, Lahore 54590, Pakistan.
Muhammad Muntazir IqbalDepartment of Chemistry, School of Science, University of Management and Technology, Lahore 54770, Pakistan.
Mohsin JavedDepartment of Chemistry, School of Science, University of Management and Technology, Lahore 54770, Pakistan.ORCID 0000-0003-3866-3216
Maha Abdallah AlnuwaiserDepartment of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.ORCID 0000-0002-3318-1739
Shahid IqbalDepartment of Chemistry, School of Natural Sciences (SNS), National University of Science and Technology (NUST), H-12, Islamabad 46000, Pakistan.ORCID 0000-0002-4607-6217
Qaiser MahmoodChemistry and Chemical Engineering Guangdong Laboratory, Shantou 515031, China.
Eslam B ElkaeedDepartment of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh 13713, Saudi Arabia.ORCID 0000-0002-2546-8035
Ayed A DeraDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia.
Hamad AlrbyawiPharmaceutics and Pharmaceutical Technology Department, College of Pharmacy, Taibah University, Medina 42353, Saudi Arabia.
Rami Adel PashameahDepartment of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah 24230, Saudi Arabia.
Eman AlzahraniDepartment of Chemistry, College of Science, Taif University, Taif 21944, Saudi Arabia.
Abd-ElAziem FaroukDepartment of Biotechnology, College of Science, Taif University, Taif 21944, Saudi Arabia.

Funding

Princess Nourah bint Abdulrahman University PNURSP2022R186Umm al-Qura University 22UQU4320141DSR05
6 · The paper itself

Abstract

Bombax ceiba L. (Family: Malvaceae) was rightly called the “silent doctor” in the past as every part of it had medicinal value. For centuries, humans have used this plant according to the traditional medicinal systems of China, Ayurveda, and tribal communities. Recently, with an emerging interest in herbals, attention has been paid to scientifically validating medicinal claims for the treatment of diabetes using secondary metabolites of B. ceiba L. flowers. In the present study, specific secondary metabolites from the flowers of B. ceiba L. were isolated in good yield using the solvent extraction methodology, and their in vitro anti-diabetic efficacy was examined. Extraction efficiency of each solvent for secondary metabolites was found in following order: water > ethanol> methanol > chloroform > petroleum ether. Quantitative analysis of secondary metabolites showed 120.33 ± 2.33 mg/gm polyphenols, 60.77 ± 1.02 mg/g flavonoids, 60.26 ± 1.20 mg/g glycosaponins, 0.167 ± 0.02 mg/g polysaccharides for water extract; 91.00 ± 1.00 mg/g polyphenols, 9.22 ± 1.02 mg/g flavonoids, 43.90 ± 0.30 mg/g glycosaponins, 0.090 ± 0.03 mg/g poly saccharides for ethanol extract; 52.00 ± 2.64 mg/g polyphenols, 35.22 ± 0.38 mg/g flavonoids, 72.26 ± 1.05 mg/g glycosaponins, 0.147 ± 0.01 mg/g polysaccharides for methanol extract; 11.33 ± 0.58 mg/g polyphenols, 23.66 ± 1.76 mg/g flavonoids, 32.8 ± 0.75 mg/g glycosaponins, 0.013 ± 0.02 mg/g polysaccharides for chloroform extract; and 3.33 ± 1.53 mg/g polyphenols, 1.89 ± 1.39 mg/g flavonoids, 21.67 ± 1.24 mg/g glycosaponins, 0.005 ± 0.01 mg/g polysaccharides for petroleum ether extract. Glucose uptake by yeast cells increased 70.38 ± 2.17% by water extract.

Indexed as

anti-diabetic activityBombax ceiba L.flavonoidsflowerpolyphenolsyeast

Identifiers

PMID36290454
PMCPMC9598353

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.