Combined Treatment with KV Channel Inhibitor 4-Aminopyridine and either γ-Cystathionine Lyase Inhibitor β-Cyanoalanine or Epinephrine Restores Blood Pressure, and Improves Survival in the Wistar Rat Model of Anaphylactic Shock.
Article in Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
14 authors at 5 institutions in 5 countries.
Abdelouahab BellouInstitute of Sciences in Emergency Medicine, Department of Emergency Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.ORCID 0000-0003-3457-5585
Nacira SennounDepartment of Cell and Molecular Biology, Team Cytokines and Nitric Oxide Synthases, Faculty of Biology, University HouariBoumediene USTHB, Bab-Ezzouar, Algiers 1611, Algeria.
Elhadi H AburawiDepartment of Pediatrics, College of Medicine and Health Sciences, UAE University, Al-Ain P.O. Box 15551, United Arab Emirates.ORCID 0000-0001-5200-9048
Richard L JayarajDepartment of Pediatrics, College of Medicine and Health Sciences, UAE University, Al-Ain P.O. Box 15551, United Arab Emirates.ORCID 0000-0003-1593-0668
Seth L AlperDivision of Nephrology and Vascular Biology Research Center, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-6228-2512
Ibrahim Abdallah AlfakiDepartment of Analytics in the Digital Era, UAE University, Al-Ain P.O. Box 15551, United Arab Emirates.ORCID 0000-0002-1639-9656
Javed YasinDepartment of Internal Medicine, College of Medicine and Health Sciences, UAE University, Al-Ain P.O. Box 15551, United Arab Emirates.ORCID 0000-0002-5867-2833
Subramanian SekarRenaissance LLC, Lakewood, NJ 08701, USA.
Mohamed ShafiuallahDepartment of Physiology, College of Medicine and Health Sciences, UAE University, Al-Ain P.O. Box 15551, United Arab Emirates.
Suhail Al-SalamDepartment of Pathology, College of Medicine and Health Sciences, UAE University, Al-Ain P.O. Box 15551, United Arab Emirates.
Abderrahim NemmarDepartment of Physiology, College of Medicine and Health Sciences, UAE University, Al-Ain P.O. Box 15551, United Arab Emirates.ORCID 0000-0002-0699-1015
Elsadig KazzamDepartment of Internal Medicine, College of Medicine and Health Sciences, UAE University, Al-Ain P.O. Box 15551, United Arab Emirates.
Paul Michel MertesPôle Anesthésie, Réanimation Chirurgicale, Hôpitaux Universitaires de Strasbourg, 67200 Strasbourg, France.
Suleiman Al-HammadiDepartment of Pediatrics, College of Medicine and Health Sciences, UAE University, Al-Ain P.O. Box 15551, United Arab Emirates.
United Arab Emirates University · AEBeth Israel Deaconess Medical Center · USHôpitaux Universitaires de Strasbourg · FRUniversity of Sciences and Technology Houari Boumediene · DZWayne State University · US
Funding
United Arab Emirates University NP-15-21
6 · The paper itself
Abstract
The mechanism of anaphylactic shock (AS) remains incompletely understood. The potassium channel blocker 4-aminopyridine (4-AP), the inhibitors of cystathionine γ-lyase (ICSE), dl-propargylglycine (DPG) or β-cyanoalanine (BCA), and the nitric oxide (NO) synthase produce vasoconstriction and could be an alternative for the treatment of AS. The aim of this study was to demonstrate the ability of L-NAME, ICSE alone or in combination with 4-AP to restore blood pressure (BP) and improve survival in ovalbumin (OVA) rats AS. Experimental groups included non-sensitized Wistar rats (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Combined Treatment with KV Channel Inhibitor 4-Aminopyridine and either γ-Cystathionine Lyase Inhibitor β-Cyanoalanine or Epinephrine Restores Blood Pressure, and Improves Survival in the Wistar Rat Model of Anaphylactic Shock. · full record | OpenQuestion