Evidence map›Paper›PMID 36290109›Full record

ArticleAntibiotics (Basel, Switzerland)2022

Discovery and Preliminary Structure-Activity Investigation of 3-Substituted-1

Steven A Li, Rebecca J Zheng, Kenneth Sue, Marie-Lise Bourguet-Kondracki, Azza Troudi, Jean Michel Brunel, Brent R Copp, Melissa M Cadelis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Steven A LiSchool of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.ORCID 0000-0001-6029-1274
Rebecca J ZhengSchool of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Kenneth SueSchool of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Marie-Lise Bourguet-KondrackiLaboratoire Molécules de Communication et Adaptation des Micro-Organismes, UMR 7245 CNRS, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France.
Azza TroudiUMR MD1 "Membranes et Cibles Thérapeutiques", U1261 INSERM, Faculté de Pharmacie, Aix-Marseille Universite, 27 bd Jean Moulin, 13385 Marseille, France.
Jean Michel BrunelUMR MD1 "Membranes et Cibles Thérapeutiques", U1261 INSERM, Faculté de Pharmacie, Aix-Marseille Universite, 27 bd Jean Moulin, 13385 Marseille, France.ORCID 0000-0002-9355-8980
Brent R CoppSchool of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.ORCID 0000-0001-5492-5269
Melissa M CadelisSchool of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.ORCID 0000-0003-3883-0109

Funding

Catalyst: Seeding Dumont d'Urville NZ-France Science & Technology Support Programme 19-UOA-057-DDUWellcome Trust
6 · The paper itself

Abstract

Antibiotics have been the cornerstone of modern medicine saving lives by virtue of being able to cure infectious diseases and to prevent infections in those who are immune compromised. Their intense use has led to a surging increase in the incidence of antibiotic-resistant bacteria resulting in a desperate need for antibiotics with new mechanisms of action. As part of our search for new antimicrobials we have screened an in-house library of compounds and identified two 3-substituted-1

Indexed as

antifungalantimicrobialimidazoleMRSA

Identifiers

PMID36290109
PMCPMC9598367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.