ArticleBiomedicines2022
Clinical and Research MRI Techniques for Assessing Spinal Cord Integrity in Degenerative Cervical Myelopathy-A Scoping Review.
Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Plasma proteomics implicates NOX-driven redox imbalance in degenerative cervical myelopathy: findings from the Australian MYelopathy Natural History Registry [AO Spine RECODE-DCM research priority number 5].Redox report : communications in free radical research · 2026Article
- Lateral Decubitus Positioning Increases Pleura-Plexus Distance in Ultrasound-Guided Supraclavicular Brachial Plexus Targeting.Pain and therapy · 2026Article
- Surgical Outcomes of Degenerative Cervical Myelopathy in Patients with Parkinson Disease: A Systematic Review.Global spine journal · 2026Review
- Comparison of DTI Parameter Ratios for Early Diagnosis of Degenerative Cervical Myelopathy.Global spine journal · 2026Article
- The ferroptosis-mediated domino effect: metabolic crosstalk from intervertebral disc degeneration to spinal deformity and cord injury: a mini review.Frontiers in neuroscience · 2026Review
- Application and performance of deep learning models for the automated diagnosis of cervical central spinal stenosis on MRI: a systematic review.Brain & spine · 2026Review
- Spinal cord diffusion tensor imaging predicts balance in degenerative cervical myelopathy.Frontiers in neuroscience · 2026Article
- Complex Lower Back Pain: A Case Report.Cureus · 2025Article
- Article
- Review Article: Diagnostic Paradigm Shift in Spine Surgery.Diagnostics (Basel, Switzerland) · 2025Review
- Degenerative Cervical Myelopathy: History, Physical Examination, and Diagnosis.Journal of clinical medicine · 2024Review
- White matter spinal tracts impairment in patients with degenerative cervical myelopathy evaluated with the magnetization transfer saturation MRI technique.Spinal cord · 2024Article
- [Cervical stenosis-Diagnostics and treatment of symptomatic spinal canal stenosis and neuroforaminal stenosis].Orthopadie (Heidelberg, Germany) · 2024Article
- Correlation Between Pre-Operative Diffusion Tensor Imaging Indices and Post-Operative Outcome in Degenerative Cervical Myelopathy: A Systematic Review and Meta-Analysis.Global spine journal · 2024Article
- Evaluation of the structural integrity of different spinal cord tracts with magnetization transfer ratio in degenerative cervical myelopathy.Neuroradiology · 2024Article
- Application of the T1w/T2w mapping technique for spinal cord assessment in patients with degenerative cervical myelopathy.Spinal cord · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDegenerative cervical myelopathy (DCM) manifests as the primary cause of spinal cord dysfunction and is non-traumatic, chronic and progressive in nature. Decompressive surgery is typically utilised to halt further disability and neurological dysfunction. The limitations of current diagnostic options surrounding assessment and prognostic potential render DCM still largely a clinical diagnosis.
aimsTo outline the limitations of current diagnostic techniques, present evidence behind novel quantitative MRI (qMRI) techniques for assessing spinal cord integrity in DCM and suggest future directions.
methodArticles published up to November 2021 were retrieved from Medline, EMBASE and EBM using key search terms: spinal cord, spine, neck, MRI, magnetic resonance imaging, qMRI, T1, T2, T2*, R2*, DTI, diffusion tensor imaging, MT, magnetisation transfer, SWI, susceptibility weighted imaging, BOLD, blood oxygen level dependent, fMRI, functional magnetic resonance imaging, functional MRI, MRS, magnetic resonance spectroscopy.
resultsA total of 2057 articles were retrieved with 68 articles included for analysis. The search yielded 2 articles on Quantitative T1 mapping which suggested higher T1 values in spinal cord of moderate-severe DCM; 43 articles on DTI which indicated a strong correlation of fractional anisotropy and modified Japanese Orthopaedic Association scores; 15 articles on fMRI (BOLD) which demonstrated positive correlation of functional connectivity and volume of activation of various connections in the brain with post-surgical recovery; 6 articles on MRS which suggested that Choline/N-acetylaspartate (Cho/NAA) ratio presents the best correlation with DCM severity; and 4 articles on MT which revealed a preliminary negative correlation of magnetisation transfer ratio with DCM severity. Notably, most studies were of low sample size with short timeframes within 6 months.
conclusionsFurther longitudinal studies with higher sample sizes and longer time horizons are necessary to determine the full prognostic capacity of qMRI in DCM.
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