Evidence map›Paper›PMID 36289861›Full record

ReviewBiomedicines2022

Cell Reprogramming for Regeneration and Repair of the Nervous System.

Isaac H Clark, Alex Roman, Emily Fellows, Swathi Radha, Susanna R Var, Zachary Roushdy, Samuel M Borer, Samantha Johnson, Olivia Chen, Jacob S Borgida and 5 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Epigenetic Dynamics in Reprogramming to Dopaminergic Neurons for Parkinson's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  6. Article
  7. Ageing in the brain: mechanisms and rejuvenating strategies.Cellular and molecular life sciences : CMLS · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Isaac H ClarkDepartment of Biomedical Engineering, Biomedical Engineering Graduate Program, University of Minnesota, Minneapolis, MN 55455, USA.
Alex RomanDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-1500-9764
Emily FellowsDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.
Swathi RadhaDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.
Susanna R VarDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-5494-4248
Zachary RoushdyStem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Samuel M BorerStem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Samantha JohnsonStem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Olivia ChenStem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Jacob S BorgidaStem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Aleta SteevensDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-7104-7816
Anala ShettyDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-1185-3183
Phoebe StrellDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-1700-015X
Walter C LowDepartment of Biomedical Engineering, Biomedical Engineering Graduate Program, University of Minnesota, Minneapolis, MN 55455, USA.
Andrew W GrandeDepartment of Biomedical Engineering, Biomedical Engineering Graduate Program, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-6474-7969
University of Minnesota · US

Funding

Training in PharmacoNeuroImmune Substance Abuse ResearchT32DA007097 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MOLITOR, THOMAS WILLIAM · 1985 to 2021
$13.1M
NIDA NIH HHS T32 DA007097
6 · The paper itself

Abstract

A persistent barrier to the cure and treatment of neurological diseases is the limited ability of the central and peripheral nervous systems to undergo neuroregeneration and repair. Recent efforts have turned to regeneration of various cell types through cellular reprogramming of native cells as a promising therapy to replenish lost or diminished cell populations in various neurological diseases. This review provides an in-depth analysis of the current viral vectors, genes of interest, and target cellular populations that have been studied, as well as the challenges and future directions of these novel therapies. Furthermore, the mechanisms by which cellular reprogramming could be optimized as treatment in neurological diseases and a review of the most recent cellular reprogramming in vitro and in vivo studies will also be discussed.

Indexed as

cell-reprograminggene therapiesneuro-regeneration

Identifiers

PMID36289861
PMCPMC9599606
OpenAlexW4306651439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.