Evidence map›Paper›PMID 36289855›Full record

ArticleBiomedicines2022

Continued Complexity of Mutations in Omicron Sublineages.

Austin N Spratt, Saathvik R Kannan, Kalicharan Sharma, Shrikesh Sachdev, Shree L Kandasamy, Anders Sönnerborg, Christian L Lorson, Kamal Singh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Austin N SprattBond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA.
Saathvik R KannanBond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA.ORCID 0000-0002-8849-955X
Kalicharan SharmaDepartment of Pharmacology, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, India.ORCID 0000-0003-0333-2521
Shrikesh SachdevBond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA.
Shree L KandasamyBond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA.
Anders SönnerborgBond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA.
Christian L LorsonDepartment of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA.ORCID 0000-0002-1023-2169
Kamal SinghBond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA.ORCID 0000-0001-6153-8929

Funding

University of Missouri System ECG-KS
6 · The paper itself

Abstract

The latest SARS-CoV-2 variant of concern (VOC), Omicron (B.1.1.529), has diversified into more than 300 sublineages. With an expanding number of newly emerging sublineages, the mutation profile is also becoming complicated. There exist mutually exclusive and revertant mutations in different sublineages. Omicron sublineages share some common mutations with previous VOCs (Alpha, Beta, Gamma, and Delta), indicating an evolutionary relationship between these VOCs. A diverse mutation profile at the spike-antibody interface, flexibility of the regions harboring mutations, mutation types, and coexisting mutations suggest that SARS-CoV-2's evolution is far from over.

Indexed as

molecular dynamicsmutant modelingOmicron sublineagesrevertant mutationsstructural flexibilityvariant of concern (VOC)

Identifiers

PMID36289855
PMCPMC9599772

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.