Evidence map›Paper›PMID 36289785›Full record

ReviewBiomedicines2022

Sarcoidosis and COVID-19: At the Cross-Road between Immunopathology and Clinical Manifestation.

Claudio Tana, Francesco Cinetto, Cesare Mantini, Nicol Bernardinello, Marco Tana, Fabrizio Ricci, Andrea Ticinesi, Tiziana Meschi, Riccardo Scarpa, Francesco Cipollone and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Claudio TanaCOVID-19 and Geriatrics Clinic, SS. Annunziata Hospital of Chieti, 66100 Chieti, Italy.
Francesco CinettoRare Diseases Referral Center, Internal Medicine 1, Ca' Foncello Hospital-AULSS2 Marca Trevigiana and Department of Medicine-DIMED, University of Padova, 35128 Padova, Italy.ORCID 0000-0001-8486-5850
Cesare MantiniDepartment of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0001-6429-8836
Nicol BernardinelloRespiratory Disease Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
Marco TanaCOVID-19 and Internal Medicine Unit, SS. Annunziata Hospital of Chieti, 66100 Chieti, Italy.ORCID 0000-0002-0899-9870
Fabrizio RicciDepartment of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-1401-6623
Andrea TicinesiInternal Medicine Unit, Geriatric-Rehabilitation Department, Azienda Ospedaliero-Universitaria Di Parma, Via Antonio Gramsci 14, 43126 Parma, Italy.ORCID 0000-0001-9171-8592
Tiziana MeschiInternal Medicine Unit, Geriatric-Rehabilitation Department, Azienda Ospedaliero-Universitaria Di Parma, Via Antonio Gramsci 14, 43126 Parma, Italy.
Riccardo ScarpaRare Diseases Referral Center, Internal Medicine 1, Ca' Foncello Hospital-AULSS2 Marca Trevigiana and Department of Medicine-DIMED, University of Padova, 35128 Padova, Italy.
Francesco CipolloneMedical Clinic, SS. Annunziata Hospital of Chieti, Department of Medicine and Science of Aging, "G. D'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.
Maria Adele GiamberardinoCOVID-19 and Geriatrics Clinic, SS. Annunziata Hospital of Chieti, Department of Medicine and Science of Aging and CAST, "G. D'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.
Paolo SpagnoloRespiratory Disease Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-1096-0596
University of Chieti-Pescara · ITUniversity of Padua · ITOspedale di Parma · ITOspedale SS. Annunziata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) has been associated with dysregulation of the immune system featuring inappropriate immune responses, exacerbation of inflammatory responses, and multiple organ dysfunction syndrome in patients with severe disease. Sarcoidosis, also known as Besnier-Boeck-Schaumann disease, is an idiopathic granulomatous multisystem disease characterized by dense epithelioid non-necrotizing lesions with varying degrees of lymphocytic inflammation. These two diseases have similar clinical manifestations and may influence each other at multiple levels, eventually affecting their clinical courses and prognosis. Notably, sarcoidosis patients are at high risk of severe COVID-19 pneumonia because of the underlying lung disease and chronic immunosuppressive treatment. In this narrative review, we will discuss interactions between sarcoidosis and COVID-19 in terms of clinical manifestations, treatment, and pathogenesis, including the role of the dysregulated renin-angiotensin system, altered immune responses involving increased cytokine levels and immune system hyperactivation, and cellular death pathways.

Indexed as

cellCOVID-19granulomaimagingimmunopathologysarcoidosisSARS-CoV-2translational medicine

Identifiers

PMID36289785
PMCPMC9599235
OpenAlexW4303946490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.