Evidence map›Paper›PMID 36289735›Full record

ReviewBiomedicines2022

Vitamin E and Non-Communicable Diseases: A Review.

Giulia Ciarcià, Simone Bianchi, Barbara Tomasello, Rosaria Acquaviva, Giuseppe Antonio Malfa, Irina Naletova, Alfonsina La Mantia, Claudia Di Giacomo

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
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  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Role of nutrition in diabetes mellitus and infections.World journal of clinical cases · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Giulia CiarciàDepartment of Drug and Health Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.
Simone BianchiDepartment of Drug and Health Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.
Barbara TomaselloDepartment of Drug and Health Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0001-6049-942X
Rosaria AcquavivaDepartment of Drug and Health Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.
Giuseppe Antonio MalfaDepartment of Drug and Health Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0002-6733-0587
Irina NaletovaInstitute of Crystallography, Research National Council, 95126 Catania, Italy.ORCID 0000-0002-3186-6355
Alfonsina La MantiaDepartment of Drug and Health Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.
Claudia Di GiacomoDepartment of Drug and Health Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0002-2665-0007
University of Catania · ITInstitute of Crystallography · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin E, a nutrient found in several foods, comprises eight lipophilic vitamers, the α-, β-, γ- and δ-tocopherols and the α-, β-, γ- and δ-tocotrienols. This vitamin is capable of exerting antioxidant and anti-inflammatory activities, and acting as immunomodulators. Despite these well-known biological activities, the findings regarding the ability of vitamin E and its serum metabolites to prevent and/or control chronic disease are often conflicting and inconsistent. In this review, we have described the metabolism of vitamin E and its interaction with the gut microbiota, considering that these factors may be partially responsible for the divergent results obtained. In addition, we focused on the correlations between vitamin E serum levels, dietary intake and/or supplementation, and the main non-communicable diseases, including diabetes mellitus, asthma, cardiovascular diseases, and the four most common cancers (breast cancer, lung cancer, colorectal cancer, and prostate cancer) with the intention of providing an overview of its health effects in the non-communicable-diseases prevention.

Indexed as

anti-inflammatoryantioxidantasthmacancercardiovascular diseasesdiabetestocopherolstocotrienolsVitamin E

Identifiers

PMID36289735
PMCPMC9599164
OpenAlexW4303614212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.