Evidence map›Paper›PMID 36289697›Full record

ReviewBiomedicines2022

Current Advances in the Management of Diabetes Mellitus.

Chinyere Aloke, Chinedu Ogbonnia Egwu, Patrick Maduabuchi Aja, Nwogo Ajuka Obasi, Jennifer Chukwu, Blessing Oluebube Akumadu, Patience Nkemjika Ogbu, Ikechukwu Achilonu

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06518486 nacompletednot on this mapstarted 2024, after this paper: background citation

The Effectiveness of Foot-Ankle Exercise and Walking Exercise on Foot Neuropathy, Stress, Quality of Life, Blood Sugar Markers, Blood Pressure, Ankle-Brachial Index, and BMI Among Diabetes Mellitus Patients

TypeinterventionalSponsorTaipei Medical UniversityRan2024 to 2025Enrolled375ConditionsDiabetic Foot, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Diabetes Type 2ArmsFoot-ankle exercise, Walking exercise, Usual care and health education
NCT07270328 nacompletednot on this mapstarted 2024, after this paper: background citation

A Pilot Study of Feasibility and Exploratory Study for a Definitive Randomised Controlled Trial of Foot-Ankle Versus Walking Exercises in Patients With Diabetes Mellitus: Effects on Neuropathy, Stress, and Quality of Life

TypeinterventionalSponsorTaipei Medical UniversityRan2024 to 2024Enrolled108ConditionsDiabete Mellitus, Diabete Type 2, Diabetic Peripheral Neuropathy, Diabetic FootArmsFoot-ankle exercise group, Walking exercise group, Control group
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Chinyere AlokeProtein Structure-Function and Research Unit, School of Molecular and Cell Biology, Faculty of Science, University of the Witwatersrand, Braamfontein, Johannesburg 2050, South Africa.
Chinedu Ogbonnia EgwuDepartment of Medical Biochemistry, Alex Ekwueme Federal University Ndufu-Alike, Abakaliki PMB 1010, Nigeria.ORCID 0000-0003-3408-5471
Patrick Maduabuchi AjaDepartment of Biochemistry, Faculty of Biological Sciences, Ebonyi State University, Abakaliki PMB 53, Nigeria.ORCID 0000-0001-7805-9027
Nwogo Ajuka ObasiDepartment of Medical Biochemistry, Alex Ekwueme Federal University Ndufu-Alike, Abakaliki PMB 1010, Nigeria.ORCID 0000-0003-1404-7427
Jennifer ChukwuJohn Hopkins Program on International Education in Gynaecology and Obstetrics, Abuja 900281, Nigeria.ORCID 0000-0002-1003-4664
Blessing Oluebube AkumaduProtein Structure-Function and Research Unit, School of Molecular and Cell Biology, Faculty of Science, University of the Witwatersrand, Braamfontein, Johannesburg 2050, South Africa.
Patience Nkemjika OgbuDepartment of Medical Biochemistry, Alex Ekwueme Federal University Ndufu-Alike, Abakaliki PMB 1010, Nigeria.
Ikechukwu AchilonuProtein Structure-Function and Research Unit, School of Molecular and Cell Biology, Faculty of Science, University of the Witwatersrand, Braamfontein, Johannesburg 2050, South Africa.
Alex Ekwueme Federal University, Ndufu-AlikeUniversity of the Witwatersrand · ZAEbonyi State University · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus (DM) underscores a rising epidemic orchestrating critical socio-economic burden on countries globally. Different treatment options for the management of DM are evolving rapidly because the usual methods of treatment have not completely tackled the primary causes of the disease and are laden with critical adverse effects. Thus, this narrative review explores different treatment regimens in DM management and the associated challenges. A literature search for published articles on recent advances in DM management was completed with search engines including Web of Science, Pubmed/Medline, Scopus, using keywords such as DM, management of DM, and gene therapy. Our findings indicate that substantial progress has been made in DM management with promising results using different treatment regimens, including nanotechnology, gene therapy, stem cell, medical nutrition therapy, and lifestyle modification. However, a lot of challenges have been encountered using these techniques, including their optimization to ensure optimal glycemic, lipid, and blood pressure modulation to minimize complications, improvement of patients' compliance to lifestyle and pharmacologic interventions, safety, ethical issues, as well as an effective delivery system among others. In conclusion, lifestyle management alongside pharmacological approaches and the optimization of these techniques is critical for an effective and safe clinical treatment plan.

Indexed as

diabetes mellitushyperglycemiananomedicinenanotechnologystem cell

Identifiers

PMID36289697
PMCPMC9599361
OpenAlexW4297982794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.