Evidence map›Paper›PMID 36289695›Full record

ArticleBiomedicines2022

Depletion of CD4 and CD8 T Cells Reduces Acute Disease and Is Not Associated with Hearing Loss in ML29-Infected STAT1-/- Mice.

Rachel A Reyna, Junki Maruyama, Emily K Mantlo, John T Manning, Satoshi Taniguchi, Tomoko Makishima, Igor S Lukashevich, Slobodan Paessler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Rachel A ReynaDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Junki MaruyamaDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0003-0088-4793
Emily K MantloDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
John T ManningDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Satoshi TaniguchiDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Tomoko MakishimaDepartment of Otolaryngology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Igor S LukashevichDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA.ORCID 0000-0001-6523-5116
Slobodan PaesslerDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
The University of Texas Medical Branch at Galveston · USUniversity of Louisville · US

Funding

Sequelae of Lassa FeverR01AI129198 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI PAESSLER, SLOBODAN · 2018 to 2022
$3.9M
UTMB Clinical and Translational Science AwardTL1TR001440 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HOMMEL, JONATHAN DEAN · 2015 to 2024
$3.4M
Viral factors responsible for Lassa virus pathogenicityR00AI156012 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MARUYAMA, JUNKI · 2023 to 2024
$498k
Viral factors responsible for Lassa virus pathogenicityK99AI156012 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MARUYAMA, JUNKI · 2021 to 2022
$177k
NCATS NIH HHS TL1 TR001440NCATS NIH HHS TL1TR001440NIAID NIH HHS K99 AI156012NIAID NIH HHS R00 AI156012NIAID NIH HHS R01 AI129198NIH HHS R01 AI129198
6 · The paper itself

Abstract

Lassa virus (LASV) is a zoonotic virus endemic to western Africa that can cause a potentially lethal and hemorrhagic disease, Lassa fever (LF). Survivors suffer a myriad of sequelae, most notably sudden onset sensorineural hearing loss (SNHL), the mechanism of which remains unclear. Unfortunately, studies aiming to identify the mechanism of these sequelae are limited due to the biosafety level 4 (BSL4) requirements of LASV itself. ML29, a reassortant virus proposed as an experimental vaccine candidate against LASV, is potentially an ideal surrogate model of LF in STAT1-/- mice due to similar phenotype in these animals. We intended to better characterize ML29 pathogenesis and potential sequelae in this animal model. Our results indicate that while both CD4 and CD8 T cells are responsible for acute disease in ML29 infection, ML29 induces significant hearing loss in a mechanism independent of either CD4 or CD8 T cells. We believe that this model could provide valuable information for viral-associated hearing loss in general.

Indexed as

arenavirusLassa feverLassa virusML29sensorineural hearing loss modelSTAT1-/- mice

Identifiers

PMID36289695
PMCPMC9598517
OpenAlexW4297973626

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.