Evidence map›Paper›PMID 36289672›Full record

ArticleBiomedicines2022

Brain Perfusion Alterations Induced by Standalone and Combined Non-Invasive Brain Stimulation over the Dorsolateral Prefrontal Cortex.

Lais Boralli Razza, Pedro Henrique Rodrigues da Silva, Geraldo F Busatto, Fábio Luis de Souza Duran, Juliana Pereira, Stefanie De Smet, Izio Klein, Tamires A Zanão, Matthias S Luethi, Chris Baeken and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Cortical thickness is related to working memory performance after non-invasive brain stimulation.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023
    Trial
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Lais Boralli RazzaServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil.
Pedro Henrique Rodrigues da SilvaServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil.
Geraldo F BusattoLaboratório de Neuroimagem em Psiquiatria (LIM-21), Instituto de Psiquiatria, Faculdade de Medicina da Universidade de São Paulo, R. Dr. Ovidio Pires de Campos 785, São Paulo 05403-000, Brazil.
Fábio Luis de Souza DuranLaboratório de Neuroimagem em Psiquiatria (LIM-21), Instituto de Psiquiatria, Faculdade de Medicina da Universidade de São Paulo, R. Dr. Ovidio Pires de Campos 785, São Paulo 05403-000, Brazil.ORCID 0000-0002-7603-6152
Juliana PereiraServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil.
Stefanie De SmetDepartment of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium.
Izio KleinServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil.ORCID 0000-0002-5345-9689
Tamires A ZanãoServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil.
Matthias S LuethiServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil.
Chris BaekenDepartment of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0001-9885-3041
Marie-Anne VanderhasseltDepartment of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium.
Carlos Alberto BuchpiguelDivisão de Medicina Nuclear (LIM-43), Instituto de Radiologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 01246-904, Brazil.
André Russowsky BrunoniServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil.
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRGhent University Hospital · BEHospital Universitário da Universidade de São Paulo · BR

Funding

São Paulo Research Foundation 2018/10861-7
6 · The paper itself

Abstract

Non-invasive brain stimulation (NIBS) interventions are promising for the treatment of psychiatric disorders. Notwithstanding, the NIBS mechanisms of action over the dorsolateral prefrontal cortex (DLPFC), a hub that modulates affective and cognitive processes, have not been completely mapped. We aimed to investigate regional cerebral blood flow (rCBF) changes over the DLPFC and the subgenual anterior cingulate cortex (sgACC) of different NIBS protocols using Single-Photon Emission Computed Tomography (SPECT). A factorial, within-subjects, double-blinded study was performed. Twenty-three healthy subjects randomly underwent four sessions of NIBS applied once a week: transcranial direct current stimulation (tDCS), intermittent theta-burst stimulation (iTBS), combined tDCS + iTBS and placebo. The radiotracer 99m-Technetium-ethylene-cysteine-dimer was injected intravenously during the NIBS session, and SPECT neuroimages were acquired after the session. Results revealed that the combination of tDCS + iTBS increased right sgACC rCBF. Cathodal and anodal tDCS increased and decreased DLPFC rCBF, respectively, while iTBS showed no significant changes compared to the placebo. Our findings suggest that the combined protocol might optimize the activity in the right sgACC and encourage future trials with neuropsychiatric populations. Moreover, mechanistic studies to investigate the effects of tDCS and iTBS over the DLPFC are required.

Indexed as

combined interventionsdorsolateral prefrontal cortex (DLPFC)neuroimagingnon-invasive brain stimulation (NIBS)Single-Photon Emission Computed Tomography (SPECT)synergistic effect

Identifiers

PMID36289672
PMCPMC9598449
OpenAlexW4297348021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.