Evidence map›Paper›PMID 36289660›Full record

ReviewBiomedicines2022

The Discovery of the Role of Outer Membrane Vesicles against Bacteria.

Sofia Combo, Sérgio Mendes, Kaare Magne Nielsen, Gabriela Jorge da Silva, Sara Domingues

Abstract readReview
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Extracellular Vesicles ofAntibiotics (Basel, Switzerland) · 2023
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sofia ComboFaculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0002-5297-7337
Sérgio MendesFaculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0002-9077-483X
Kaare Magne NielsenDepartment of Life Sciences and Health, Faculty of Health Sciences at Oslo Metropolitan University, 0130 Oslo, Norway.ORCID 0000-0002-7217-2114
Gabriela Jorge da SilvaFaculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0002-7479-8540
Sara DominguesFaculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0002-8879-5113

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gram-negative bacteria are intrinsically resistant to many commercialized antibiotics. The outer membrane (OM) of Gram-negative bacteria prevents the entry of such antibiotics. Outer membrane vesicles (OMV) are naturally released from the OM of Gram-negative bacteria for a range of purposes, including competition with other bacteria. OMV may carry, as part of the membrane or lumen, molecules with antibacterial activity. Such OMV can be exposed to and can fuse with the cell surface of different bacterial species. In this review we consider how OMV can be used as tools to deliver antimicrobial agents. This includes the characteristics of OMV production and how this process can be used to create the desired antibacterial activity of OMV.

Indexed as

antimicrobial activityGram-negative bacteriaGram-positive bacteriaouter membrane vesicles

Identifiers

PMID36289660
PMCPMC9598313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.