Evidence map›Paper›PMID 36289630›Full record

ArticleBiomedicines2022

Persistent Depletion of Neuroprotective Factors Accompanies Neuroinflammatory, Neurodegenerative, and Vascular Remodeling Spectra in Serum Three Months after Non-Emergent Cardiac Surgery.

Krzysztof Laudanski, Da Liu, Tony Okeke, Mariana Restrepo, Wilson Y Szeto

Abstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Krzysztof LaudanskiDepartment of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-7373-0851
Da LiuDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110055, China.
Tony OkekeDepartment of Bioengineering, Drexel University, Philadelphia, PA 19104, USA.
Mariana RestrepoCollege of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wilson Y SzetoDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA.

Funding

UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI VAN DEERLIN, VIVIANNA M · 1991 to 2020
$35.1M
Epigenetic mediated long-term aberrations in myeloid cells after critical illnessK23GM120630 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI LAUDANSKI, KRZYSZTOF · 2017 to 2020
$783k
NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG10124NIGMS NIH HHS K23 GM120630
6 · The paper itself

Abstract

We hypothesized that the persistent depletion of neuroprotective markers accompanies neuroinflammation and neurodegeneration in patients after cardiac surgery. A total of 158 patients underwent elective heart surgery with their blood collected before surgery (t

Indexed as

amyloidapoEatypical neurodegeneration NF-Lcardiac surgeryCCL28clusterinfetuinGFAPNCAM-1neurodegenerationneuroinflammationneuroprotection

Identifiers

PMID36289630
PMCPMC9598177

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.