Evidence map›Paper›PMID 36289594›Full record

ArticleBiomedicines2022

Resistin Modulates the Functional Activity of Colostral Macrophages from Mothers with Obesity and Diabetes.

Letícia Damas Leão Dalcin, Danny Laura Gomes Fagundes-Triches, Adriele Ataides de Queiroz, André Henrique Furtado Torres, Danielle Cristina Honorio França, Tatiane Araújo Soares, Luana Cristina da Silva Ramos, Carla Roberta Silva Souza Antônio, Mahmi Fujimori, Eduardo Luzia França and 1 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Gestational Diabetes Mellitus and Colostral Appetite-Regulating Adipokines.International journal of molecular sciences · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Letícia Damas Leão DalcinInstitute of Biological and Health Science, Federal University of Mato Grosso, Av. Valdon Varjão, 6390, Barra do Garças 78698-091, Mato Grosso, Brazil.
Danny Laura Gomes Fagundes-TrichesInstitute of Biological and Health Science, Federal University of Mato Grosso, Av. Valdon Varjão, 6390, Barra do Garças 78698-091, Mato Grosso, Brazil.
Adriele Ataides de QueirozInstitute of Biological and Health Science, Federal University of Mato Grosso, Av. Valdon Varjão, 6390, Barra do Garças 78698-091, Mato Grosso, Brazil.
André Henrique Furtado TorresInstitute of Biological and Health Science, Federal University of Mato Grosso, Av. Valdon Varjão, 6390, Barra do Garças 78698-091, Mato Grosso, Brazil.
Danielle Cristina Honorio FrançaInstitute of Biological and Health Science, Federal University of Mato Grosso, Av. Valdon Varjão, 6390, Barra do Garças 78698-091, Mato Grosso, Brazil.
Tatiane Araújo SoaresInstitute of Biological and Health Science, Federal University of Mato Grosso, Av. Valdon Varjão, 6390, Barra do Garças 78698-091, Mato Grosso, Brazil.
Luana Cristina da Silva RamosInstitute of Biological and Health Science, Federal University of Mato Grosso, Av. Valdon Varjão, 6390, Barra do Garças 78698-091, Mato Grosso, Brazil.ORCID 0000-0003-1440-5087
Carla Roberta Silva Souza AntônioInstitute of Biological and Health Science, Federal University of Mato Grosso, Av. Valdon Varjão, 6390, Barra do Garças 78698-091, Mato Grosso, Brazil.
Mahmi FujimoriInstitute of Biological and Health Science, Federal University of Mato Grosso, Av. Valdon Varjão, 6390, Barra do Garças 78698-091, Mato Grosso, Brazil.
Eduardo Luzia FrançaInstitute of Biological and Health Science, Federal University of Mato Grosso, Av. Valdon Varjão, 6390, Barra do Garças 78698-091, Mato Grosso, Brazil.
Adenilda Cristina Honorio-FrançaInstitute of Biological and Health Science, Federal University of Mato Grosso, Av. Valdon Varjão, 6390, Barra do Garças 78698-091, Mato Grosso, Brazil.ORCID 0000-0002-0452-9804
Universidade Federal de Mato Grosso · BR

Funding

National Council for Scientific and Technological Development 403383/2016-1
6 · The paper itself

Abstract

backgroundObesity and diabetes are major public health problems. Resistin is an adipokine that links the two diseases. There are few reports regarding colostrum cells and resistin from mothers with obesity and diabetes. Thus, this study aimed to determine the functional activity of macrophages present in the breast milk and colostrum of diabetic mothers with obesity and the effects of resistin on these cells.

methodsThe women were divided according to BMI and glycemic status into normal weight non-diabetic, obese non-diabetic, normal weight type 2 diabetic, or obese type 2 diabetic groups. ELISA determined the resistin in colostrum. The cell subsets and apoptosis were determined by flow cytometry and the functional activity of cells by fluorescence microscopy.

resultsThe resistin levels were higher in the colostrum from diabetic mothers with obesity. The frequencies of CD14

conclusionThe data suggest that hyperglycemia associated with low-grade inflammation caused by obesity affects the percentage of cells expressing CD14

Indexed as

cellscolostrumdiabetesobesityresistin

Identifiers

PMID36289594
PMCPMC9598095
OpenAlexW4296467421

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.