Evidence map›Paper›PMID 36289390›Full record

ArticleScientific reports2022

Deep learning-based diagnosis of Alzheimer's disease using brain magnetic resonance images: an empirical study.

Jun Sung Kim, Ji Won Han, Jong Bin Bae, Dong Gyu Moon, Jin Shin, Juhee Eliana Kong, Hyungji Lee, Hee Won Yang, Eunji Lim, Jun Yup Kim and 10 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 1 country.

Jun Sung Kim *Institute of Human Behavioral Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.
Ji Won Han *Department of Neuropsychiatry, Seoul National University Bundang Hospital, 82, Gumi-Ro 173 Beon-Gil, Bundang-Gu, Seongnam-Si, Gyeonggi-Do, 13620, Republic of Korea.
Jong Bin BaeDepartment of Neuropsychiatry, Seoul National University Bundang Hospital, 82, Gumi-Ro 173 Beon-Gil, Bundang-Gu, Seongnam-Si, Gyeonggi-Do, 13620, Republic of Korea.
Dong Gyu MoonDepartment of Neuropsychiatry, Seoul National University Bundang Hospital, 82, Gumi-Ro 173 Beon-Gil, Bundang-Gu, Seongnam-Si, Gyeonggi-Do, 13620, Republic of Korea.
Jin ShinDepartment of Neuropsychiatry, Seoul National University Bundang Hospital, 82, Gumi-Ro 173 Beon-Gil, Bundang-Gu, Seongnam-Si, Gyeonggi-Do, 13620, Republic of Korea.
Juhee Eliana KongDepartment of Neuropsychiatry, Seoul National University Bundang Hospital, 82, Gumi-Ro 173 Beon-Gil, Bundang-Gu, Seongnam-Si, Gyeonggi-Do, 13620, Republic of Korea.
Hyungji LeeDepartment of Neuropsychiatry, Seoul National University Bundang Hospital, 82, Gumi-Ro 173 Beon-Gil, Bundang-Gu, Seongnam-Si, Gyeonggi-Do, 13620, Republic of Korea.
Hee Won YangDepartment of Psychiatry, Chungnam National University Hospital, Daejeon, Republic of Korea.
Eunji LimDepartment of Neuropsychiatry, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea.
Jun Yup KimDepartment of Neurology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Leonard SunwooDepartment of Radiology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Se Jin ChoDepartment of Radiology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Dongsoo LeeVUNO Inc., Seoul, Republic of Korea.
Injoong KimDepartment of Radiology, Veterans Health Service Medical Center, Seoul, Republic of Korea.
Sang Won HaDepartment of Neurology, Veterans Health Service Medical Center, Seoul, Republic of Korea.
Min Ju KangDepartment of Neurology, Veterans Health Service Medical Center, Seoul, Republic of Korea.
Chong Hyun SuhDepartment of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Woo Hyun ShimDepartment of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Sang Joon KimDepartment of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Ki Woong KimInstitute of Human Behavioral Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea. kwkimmd@snu.ac.kr.
Seoul National University Bundang Hospital · KRSeoul National University · KRUlsan College · KRVeterans Health Service Medical Center · KRChungnam National University Hospital · KRGyeongsang National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The limited accessibility of medical specialists for Alzheimer's disease (AD) can make obtaining an accurate diagnosis in a timely manner challenging and may influence prognosis. We investigated whether VUNO Med-DeepBrain AD (DBAD) using a deep learning algorithm can be employed as a decision support service for the diagnosis of AD. This study included 98 elderly participants aged 60 years or older who visited the Seoul Asan Medical Center and the Korea Veterans Health Service. We administered a standard diagnostic assessment for diagnosing AD. DBAD and three panels of medical experts (ME) diagnosed participants with normal cognition (NC) or AD using T1-weighted magnetic resonance imaging. The accuracy (87.1% for DBAD and 84.3% for ME), sensitivity (93.3% for DBAD and 80.0% for ME), and specificity (85.5% for DBAD and 85.5% for ME) of both DBAD and ME for diagnosing AD were comparable; however, DBAD showed a higher trend in every analysis than ME diagnosis. DBAD may support the clinical decisions of physicians who are not specialized in AD; this may enhance the accessibility of AD diagnosis and treatment.

Indexed as

Alzheimer DiseaseDeep LearningAgedAlgorithmsBrainHumansMagnetic Resonance Imaging

Identifiers

PMID36289390
PMCPMC9606115
OpenAlexW4307565777

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.