ArticleNature2022
Subtype-specific 3D genome alteration in acute myeloid leukaemia.
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In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 1 pooled it
32.1field-weighted citation impact, top 1% of its field
What it found
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Who cites it
138 citing papers in PubMed, 1 synthesis or guideline pooled it, 202 citations in OpenAlex.
- Meta-analysis and transcriptomic analysis reveal that NKRF and ZBTB17 regulate the NF-κB signaling pathway, contributing to the shared molecular mechanisms of Alzheimer's disease and atherosclerosis.CNS neuroscience & therapeutics · 2024Pooled it
- 4D nucleome landscape reveals dissolution of bipartite active X chromosome in liver cancer development.Nature cell biology · 2026Article
- Identification of differential topologically associating domains from low sequencing depth and pseudobulk chromatin contact maps.Genome research · 2026Article
- Spatial chromatin architecture and accessibility co-profiling of mammalian tissues.Nature methods · 2026Article
- Alterations in 3D-DNA architecture drive unique leukemic profiles in IDH1- and DNMT3A-mutant acute myeloid leukemia.Leukemia · 2026Article
- cPRC1.2 and CTCF-mediated transition from poised to active chromatin loops at bivalent genes.EMBO reports · 2026Article
- Mega-enhancers compartmentalize transcriptionally active long genes in the brain.Nature cell biology · 2026Article
- Origins and consequences of oncogenic 3D chromatin remodelling.Nature reviews. Cancer · 2026Review
- Metabolically and epigenetically reprogrammed splenic TRNP1Nature genetics · 2026Article
- Article
- Intracellular iron homeostasis-regulated epigenetic reprogramming contributes to -7/del(7q) leukemia.Nature communications · 2026Article
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- Targeting ZMIZ1 induces differentiation in acute myeloid leukemia via chromatin remodeling.Signal transduction and targeted therapy · 2026Article
- Persistent homology-based multiscale Hi-C analysis uncovers TADs-mediated gene regulation.Scientific reports · 2026Article
- MECP2 mutations disrupt pluripotent stem cell fate through remodeling of the three-dimensional genome.Cell death & disease · 2026Article
- Inhibition of Histone Lactylation by Dichloromethane Extract From Patrinia scabiosaefolia Fisch on Acute Myeloid Leukemia Cells.Chemistry & biodiversity · 2026Article
- Connecting multiway enhancer-promoter interactions to changes in gene expression in cancer.bioRxiv : the preprint server for biology · 2026Article
- Chromatin architecture and physical constriction cooperate in phenotype switching and cancer cell dissemination.bioRxiv : the preprint server for biology · 2026Article
- Phase separation of β-catenin assembles active loop hubs in colorectal cancer.Genome biology · 2026Article
- Genomic structural variations contribute to inform prognosis in patients with cytogenetically normal acute myeloid leukemia.Blood cancer journal · 2026Article
78 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 6 institutions in 2 countries.
Jie Xu *Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-0020-5017
Fan Song *Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-5836-354X
Huijue LyuDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Mikoto KobayashiDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-5007-5877
Baozhen ZhangDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Ziyu ZhaoDepartment of Neurobiology, Northwestern University, Evanston, IL, USA.
Ye HouDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Xiaotao WangDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-3531-2157
Yu LuanDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-1778-9071
Bei JiaDepartment of Medicine, Division of Hematology and Oncology, Penn State Cancer Institute, Penn State University, Hershey, PA, USA.
Lena StasiakDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Josiah Hiu-Yuen WongDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Qixuan WangDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Qi JinDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Qiushi JinDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Yihao FuDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Hongbo YangDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Ross C HardisonDepartment of Biochemistry and Molecular Biology, Huck Institutes of Life Sciences, Penn State University, State College, PA, USA.ORCID http://orcid.org/0000-0003-4084-7516
Sinisa DovatDepartment of Medicine, Division of Hematology and Oncology, Penn State Cancer Institute, Penn State University, Hershey, PA, USA.
Leonidas C PlataniasRobert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Yarui DiaoDepartment of Cell Biology, Duke University School of Medicine, Durham, NC, USA.
Yue YangDepartment of Neurobiology, Northwestern University, Evanston, IL, USA.
Tomoko YamadaDepartment of Neurobiology, Northwestern University, Evanston, IL, USA.
Aaron D VinyDivision of Hematology/Oncology and Columbia Stem Cell Initiative, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-7039-0110
Ross L LevineMemorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-7884-1905
David ClaxtonDepartment of Medicine, Division of Hematology and Oncology, Penn State Cancer Institute, Penn State University, Hershey, PA, USA.
James R BroachDepartment of Biochemistry and Molecular Biology, Penn State College of Medicine, Penn State University, Hershey, PA, USA.ORCID http://orcid.org/0000-0003-1197-0312
Hong ZhengDepartment of Medicine, Division of Hematology and Oncology, Penn State Cancer Institute, Penn State University, Hershey, PA, USA. hzheng@pennstatehealth.psu.edu.ORCID http://orcid.org/0000-0002-5024-5538
Feng YueDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. yue@northwestern.edu.ORCID http://orcid.org/0000-0002-7954-5462
Northwestern University · USPenn State Milton S. Hershey Medical Center · USPennsylvania State University · USColumbia University · USDuke University · USMemorial Sloan Kettering Cancer Center · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MWomen's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI JOHN N. NORTON · 1985 to 2026
$174.8MTRANS-NETWORK PROJECTSU54CA143869 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KATH, WILLIAM LAWRENCE · 2009 to 2013
$12.8MSynergistic role of signaling and epigenetics in leukemic transformationR35CA197594 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Ross L Levine · 2017 to 2026
$11.4MVISION: ValIdated Systematic IntegratiON of epigenomic dataR24DK106766 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI BLOBEL, GERD A, BODINE, DAVID M. · 2016 to 2020
$6.2MImpact of genetic variants on gene regulation and 3D genome organization in human diseasesR35GM124820 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Feng Yue · 2017 to 2026
$4.0MThe cohesin complex as a tumor suppressor in myeloid leukemiaR01CA216421 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI AIFANTIS, IANNIS, LEVINE, ROSS L · 2017 to 2021
$2.5MMechanisms of Genome Organization in Brain Development and BehaviorU01DA053691 · NIDA · NORTHWESTERN UNIVERSITY · PI YAMADA, TOMOKO · 2020 to 2024
$2.4MVisualization, modeling and validation of chromatin interaction dataR01HG009906 · NHGRI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI YUE, FENG · 2018 to 2022
$2.0MThe WashU 4DN Network Data Coordination and Integration CenterU01CA200060 · NCI · WASHINGTON UNIVERSITY · PI WANG, TING · 2015 to 2019
$1.9MTargeting CK2 oncogenic pathway to overcome drug resistance in high-risk leukemiaR01CA213912 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI DOVAT, SINISA · 2017 to 2021
$1.8MComputational methods to identify neo-TADs and enhancer-hijacking in rearranged genomesR01HG011207 · NHGRI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI YUE, FENG · 2021 to 2024
$1.6MNCI NIH HHS K08 CA215317NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014236NCI NIH HHS R01 CA213912NCI NIH HHS R01 CA216421NCI NIH HHS R35 CA197594NCI NIH HHS U01 CA200060NCI NIH HHS U54 CA143869NHGRI NIH HHS R01 HG009906NHGRI NIH HHS R01 HG011207NIDA NIH HHS U01 DA053691NIDDK NIH HHS R24 DK106766NIGMS NIH HHS R35 GM124820
Abstract
Acute myeloid leukaemia (AML) represents a set of heterogeneous myeloid malignancies, and hallmarks include mutations in epigenetic modifiers, transcription factors and kinases
Indexed as
Genome, HumanLeukemia, Myeloid, AcuteCCCTC-Binding FactorChromatinCRISPR-Cas SystemsDNA (Cytosine-5-)-MethyltransferasesDNA MethylationEnhancer Elements, GeneticGene Expression Regulation, LeukemicGene SilencingHumansPromoter Regions, GeneticReproducibility of ResultsSequence AnalysisSulfitesCCCTC-Binding FactorChromatinCTCF protein, humanDNA (Cytosine-5-)-Methyltransferaseshydrogen sulfiteSulfites
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.