ArticleNature2022
Phenotypic plasticity and genetic control in colorectal cancer evolution.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
16.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 169 citations in OpenAlex.
- A single-cell lens into the co-evolution of genotypes and phenotypes in cancer.Nature reviews. Cancer · 2026Review
- Single-cell epigenomics of colorectal cancer.Experimental & molecular medicine · 2026Review
- CRISPRa-identified transcription factors reprogram glioblastoma into dendritic cell-like cells to elicit systemic antitumor immunity.Cell reports. Medicine · 2026Article
- A guide to understanding tumour evolution through the lens of population genetics.Nature reviews. Cancer · 2026Review
- Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis.Nature genetics · 2026Article
- Article
- Identifying phenotype-genotype-function coupling in 3D organoid imaging using Shape, Appearance and Motion Phenotype Observation Tool (SPOT).Nature communications · 2026Article
- Multi-regional transcriptomics reveals robust consensus subtypes beyond tumor heterogeneity of breast cancer.Translational oncology · 2026Article
- Fluctuating environment causes neoplastic transition and epithelial-mesenchymal plasticity in human cells.Research square · 2026Article
- Patient-derived organoids for precision oncology in colorectal cancer: from tumor modeling to clinical translation.Molecular cancer · 2026Review
- Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- IGF2BP3 is essential for the growth heterogeneity of colorectal adenoma cells by regulating MYC.iScience · 2026Article
- Fluctuating DNA methylation sites encode colorectal tumour growth history.bioRxiv : the preprint server for biology · 2026Article
- Clonal evolution and mutational trajectories of metastatic colorectal cancer shaped by anticancer therapies.Nature communications · 2026Article
- Geospatial genetic evolution and phenotypic plasticity in triple-negative breast cancer.Genome medicine · 2026Article
- Article
- tugMedi: simulator of cancer-cell evolution for personalized medicine based on the genomic data of patients.NPJ systems biology and applications · 2026Article
- Targeting the epigenome and the integrated stress response to normalize colorectal cancer subclonal plasticity and progression.Cell death & disease · 2026Article
- Transcriptomic Plasticity Is a Hallmark of Metastatic Pancreatic Cancer.Cancer research · 2026Article
- Single-cell and spatial profiling in cancer biology and clinical oncology.Nature cancer · 2026Review
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 10 institutions in 3 countries.
Jacob Househam *Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0003-3199-336X
Timon Heide *Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-1386-7469
George D CresswellCentre for Evolution and Cancer, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0003-3303-068X
Inmaculada SpiteriCentre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
Chris KimberleyCentre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Luis ZapataCentre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
Claire LynnCentre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
Chela JamesCentre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
Maximilian MossnerCentre for Evolution and Cancer, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0001-9751-3803
Javier Fernandez-MateosCentre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
Alessandro VincetiComputational Biology Research Centre, Human Technopole, Milan, Italy.
Ann-Marie BakerCentre for Evolution and Cancer, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0001-8905-9137
Calum GabbuttCentre for Evolution and Cancer, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0003-1946-4780
Alison BernerCentre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Melissa SchmidtCentre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-7682-0932
Bingjie ChenCentre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
Eszter LakatosCentre for Evolution and Cancer, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-7221-6850
Vinaya GunasriCentre for Evolution and Cancer, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-9292-6470
Daniel NicholCentre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
Helena CostaUCL Cancer Institute, University College London, London, UK.
Miriam MitchinsonHistopathology Department, University College London Hospitals NHS Foundation Trust, London, UK.
Daniele RamazzottiDepartment of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Benjamin WernerCentre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-6857-8699
Francesco IorioComputational Biology Research Centre, Human Technopole, Milan, Italy.ORCID http://orcid.org/0000-0001-7063-8913
Marnix JansenUCL Cancer Institute, University College London, London, UK.ORCID http://orcid.org/0000-0003-0645-564X
Giulio CaravagnaCentre for Evolution and Cancer, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0003-4240-3265
Chris P BarnesDepartment of Cell and Developmental Biology, University College London, London, UK.ORCID http://orcid.org/0000-0002-9459-1395
Darryl ShibataDepartment of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
John BridgewaterUCL Cancer Institute, University College London, London, UK.ORCID http://orcid.org/0000-0001-9186-1604
Manuel Rodriguez-JustoUCL Cancer Institute, University College London, London, UK.ORCID http://orcid.org/0000-0001-5007-1761
Luca MagnaniDepartment of Surgery and Cancer, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-7534-0785
Andrea SottorivaCentre for Evolution and Cancer, The Institute of Cancer Research, London, UK. andrea.sottoriva@fht.org.ORCID http://orcid.org/0000-0001-6709-9533
Trevor A GrahamCentre for Evolution and Cancer, The Institute of Cancer Research, London, UK. trevor.graham@icr.ac.uk.ORCID http://orcid.org/0000-0001-9582-1597
Institute of Cancer Research · GBCRUK Lung Cancer Centre of Excellence · GBQueen Mary University of London · GBHuman Technopole · ITImperial College London · GBUniversity College London · GBUniversity College London Hospitals NHS Foundation Trust · GBUniversity of Milano-Bicocca · ITUniversity of Southern California · USUniversity of Trieste · IT
Funding
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI David V Conti · 2016 to 2026
$25.5MThe Role of the Microbiome in Cancer Suppression and Susceptibility Across SpeciesU54CA217376 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI MALEY, CARLO · 2018 to 2022
$8.6MCancer Research UK 19771Cancer Research UK 22909Cancer Research UK 23110Cancer Research UK 26815Cancer Research UK A19771Cancer Research UK A22909Cancer Research UK A26815Medical Research Council MR/P000789/1NCI NIH HHS P01 CA196569NCI NIH HHS U54 CA217376Wellcome TrustWellcome Trust 105104/Z/14/ZWellcome Trust 202778/B/16/ZWellcome Trust 202778/Z/16/ZWellcome Trust 209409/Z/17/Z
Abstract
Genetic and epigenetic variation, together with transcriptional plasticity, contribute to intratumour heterogeneity
Indexed as
Adaptation, PhysiologicalColorectal NeoplasmsGene Expression Regulation, NeoplasticPhenotypeClone CellsExome SequencingHumansMutationTranscription, Genetic
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.