ArticleSchizophrenia (Heidelberg, Germany)2022
In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia.
Registry-linked trialOpen access · diamondAbstract read
In one paragraph
Article in Schizophrenia (Heidelberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07759895 (Combination Therapy of Deferiprone and N-Acetylcysteine for Treating Negative Symptoms in Schizophrenia), which is not on this map. Cited by 31 papers.
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31citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT07759895 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation
Combination Therapy of Deferiprone and N-Acetylcysteine for Treating Negative Symptoms in Schizophrenia
Who cites it
31 citing papers in PubMed, 34 citations in OpenAlex.
- Effects of Schizophrenia, Bipolar Disorder, and Depression on Cardiopulmonary and Abdominal Organ Structure.Biological psychiatry global open science · 2026Article
- Iron dyshomeostasis and its neurobiological mechanisms in psychiatric disorders.Molecular psychiatry · 2026Review
- Cortical Iron and Mesostriatal Dopamine Function in Schizophrenia: A Positron Emission Tomography and Magnetic Resonance Imaging Study.Schizophrenia bulletin · 2026Article
- Ferroptosis in neurological diseases: moving towards therapeutic intervention.Molecular psychiatry · 2026Review
- Development and in vivo proof-of-concept of delayed alternating nutation tailored excitation point resolved spectroscopy (dante-press): a frequency-selective single voxel spectroscopy sequence applied to in vivo measurements of naa and glu at 7.0 T.Magma (New York, N.Y.) · 2026Article
- Aging in Schizophrenia: Perspectives on Molecular Mechanisms and a Mini-review.Schizophrenia bulletin · 2026Review
- Voxel-Wise Whole-Brain Analysis in Quantitative Susceptibility Mapping: A Narrative Review.Human brain mapping · 2026Review
- The role of low subcortical iron, white matter myelin, and oligodendrocytes in schizophrenia: a quantitative susceptibility mapping and diffusion tensor imaging study.Molecular psychiatry · 2026Article
- Iron dyshomeostasis in neuropsychiatric disorders.Frontiers in psychiatry · 2026Review
- Quantitative susceptibility mapping at 7T as a biomarker of post- and interictal extravascular iron in patients with focal epilepsy.EBioMedicine · 2025Article
- Brain iron distribution in transdiagnostic mental health burden.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Reduced Brain Iron and Striatal Hyperdopaminergia in Schizophrenia: A Quantitative Susceptibility Mapping MRI and PET Study.The American journal of psychiatry · 2025Article
- Association between endogenous lactate accumulation and dysregulated activation of the NLRP3 inflammasome pathway in schizophrenia.Scientific reports · 2025Observational
- Ferroptosis in schizophrenia: Mechanisms and therapeutic potentials (Review).Molecular medicine reports · 2025Review
- Causal associations between iron levels in subcortical brain regions and psychiatric disorders: a Mendelian randomization study.Translational psychiatry · 2025Article
- In defence of ferroptosis.Signal transduction and targeted therapy · 2025Review
- IRONMAP: Iron network mapping and analysis protocol for detecting over-time brain iron abnormalities in neurological disease.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Quantitative susceptibility mapping of deep brain nuclei in 22q11.2 deletion syndrome.Frontiers in psychiatry · 2025Article
- Identification and Correlation Analysis of Ferroptosis-Related Genes in Three Brain Regions of Patients with Schizophrenia.Actas espanolas de psiquiatria · 2024Article
- Leveraging ultra-high field (7T) MRI in psychiatric research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
Corrections and comments
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Authors and funding
22 authors at 6 institutions in 4 countries.
Parsa RavanfarMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia. sravanfar@student.unimelb.edu.au.
Warda T SyedaMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.ORCID http://orcid.org/0000-0001-6294-622X
Mahesh JayaramDepartment of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Australia.
R Jarrett RushmorePsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Bradford MoffatMelbourne Brain Centre Imaging Unit, Department of Radiology, University of Melbourne, Parkville, VIC, Australia.
Alexander P LinPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Amanda E LyallPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8049-516X
Antonia H MerrittMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.
Negin YaghmaieMelbourne Brain Centre Imaging Unit, Department of Radiology, University of Melbourne, Parkville, VIC, Australia.
Liliana LaskarisMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.
Sandra LuzaMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.
Carlos M OpazoMelbourne Dementia Research Centre, The Florey Institute of Neuroscience & Mental Health, and The University of Melbourne, Parkville, VIC, Australia.
Benny LibergCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
M Mallar ChakravartyCerebral Imaging Center, Douglas Research Centre, Montreal, QC, Canada.
Gabriel A DevenyiCerebral Imaging Center, Douglas Research Centre, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-7766-1187
Patricia DesmondDepartment of Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
Vanessa L CropleyMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.ORCID http://orcid.org/0000-0003-0029-1525
Nikos MakrisPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Martha E ShentonPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Ashley I BushMelbourne Dementia Research Centre, The Florey Institute of Neuroscience & Mental Health, and The University of Melbourne, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0001-8259-9069
Dennis VelakoulisMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.
Christos PantelisMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia. cpant@unimelb.edu.au.ORCID http://orcid.org/0000-0002-9565-0238
The University of Melbourne · AUBrigham and Women's Hospital · USMcGill University · CAThe Royal Melbourne Hospital · AUBoston University · USKarolinska Institutet · SE
Funding
Neural substrates of diffusion imaging in cognitively aging rhesus monkeysR01AG042512 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK, MAKRIS, NIKOLAOS · 2013 to 2023
$6.5MMapping the superficial white matter connectome of the human brain using ultra high resolution multi-contrast diffusion MRIR01MH125860 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MAKRIS, NIKOLAOS, O'DONNELL, LAUREN JEAN · 2021 to 2025
$4.1MHigh Resolution, Comprehensive Atlases of the Human Brain MorphologyR01MH112748 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI BOUIX, SYLVAIN, KUBICKI, MAREK · 2018 to 2022
$4.1MPatient-specific, Effective, and Rational Functional Connectivity Targeting for DBS in OCDR01MH111917 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DOUGHERTY, DARIN D, MAKRIS, NIKOLAOS · 2017 to 2019
$2.1MMentoring and neuroimaging research on new targets for DBS in OCDK24MH116366 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MAKRIS, NIKOLAOS · 2018 to 2022
$817kModulating Inhibitory Control Networks In Gambling Disorder With Theta Burst StimulationR21DA042271 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI CAMPRODON, JOAN A, MAKRIS, NIKOLAOS · 2017 to 2018
$439kDepartment of Health | National Health and Medical Research Council (NHMRC) 1150083Department of Health | National Health and Medical Research Council (NHMRC) 1177370Department of Health | National Health and Medical Research Council (NHMRC) 1194028Department of Health | National Health and Medical Research Council (NHMRC) 1196508Royal Melbourne Hospital (RMH) GIA-030H2016U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 1 K01 MH115247-01A1U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 1K24MH110807-01A1U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 5 U01MH109977U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) K24MH116366U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH111917U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH112748U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH125860U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG042512U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R21DA042271
Abstract
Brain iron is central to dopaminergic neurotransmission, a key component in schizophrenia pathology. Iron can also generate oxidative stress, which is one proposed mechanism for gray matter volume reduction in schizophrenia. The role of brain iron in schizophrenia and its potential link to oxidative stress has not been previously examined. In this study, we used 7-Tesla MRI quantitative susceptibility mapping (QSM), magnetic resonance spectroscopy (MRS), and structural T
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NCT07759895ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.