ReviewReproductive sciences (Thousand Oaks, Calif.)2023
The Role of Interferon (IFN)-γ in Extravillous Trophoblast Cell (EVT) Invasion and Preeclampsia Progression.
Review in Reproductive sciences (Thousand Oaks, Calif.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Placental dysfunction reflects endocrine impairment and trophoblast alterations in polycystic ovarian syndrome.Scientific reports · 2026Article
- Mesenchymal stem cells for recurrent miscarriage.Journal of translational medicine · 2026Review
- IFN-γ+ NK cells as a potential predictor of pregnancy loss in unexplained recurrent pregnancy loss.International journal of medical sciences · 2026Article
- Persistent Human T-Lymphotropic Virus Type 1 (HTLV-1) Infection in the Placenta of Pregnant Women.Journal of medical virology · 2025Article
- Immune Dysregulation at the Maternal-Fetal Interface Exacerbates Adverse Pregnancy Outcomes in an Inflammatory Arthritis Murine Model.Biomedicines · 2025Article
- Differences in lymphocyte subsets of spiral artery associated with impaired vascular remodeling in hypertensive disorders of pregnancy.BMC pregnancy and childbirth · 2025Article
- Immune dysregulation of decidual NK cells mediated by GRIM19 downregulation contributes to the occurrence of recurrent pregnancy loss.Molecular and cellular biochemistry · 2025Article
- Immunohistochemical analysis reveals higher Myxovirus resistance protein 1 expression and increased macrophage count in placentas from patients with systemic rheumatic diseases.Rheumatology international · 2025Article
- The Impact of Inflammatory Cytokines on Recurrent Pregnancy Loss: A Preliminary Investigation.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- The Placenta as an Immunological Environment.British journal of biomedical science · 2025Review
- Article
- Effect of Granzyme K, FasL and Interferon-γ Expression in Placentas with Preeclampsia.Biomedicines · 2024Article
- Article
- Deciphering the immunological interactions: targeting preeclampsia with Hydroxychloroquine's biological mechanisms.Frontiers in pharmacology · 2024Review
- Exploring the role of T helper subgroups and their cytokines in the development of pregnancy-induced hypertension.Frontiers in immunology · 2023Article
- Roles of immune microenvironment in the female reproductive maintenance and regulation: novel insights into the crosstalk of immune cells.Frontiers in immunology · 2023Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The involvement of the immune system in pregnancy is a controversial subject. The functions of T helper (Th) 1 and Th2 cells have been proposed, that Th1 cytokines promoting allograft rejection may impair pregnancy, whereas Th2-type cytokines suppressing Th1 responses improve allograft tolerance and hence embryonic survival. Maternal-fetal tolerance begins in the uterus; therefore, optimal adaptation to the fetus is the result of a complex interference. The invasion of extravillous trophoblast cells (EVTs) into the decidua and the inner third of the myometrium is essential for a healthy pregnancy. The mechanisms that influence trophoblast invasion are unknown; however, cytokines from uterine natural killer (uNK) cells, NKT cells, macrophages, and T cells appear to be involved. All these cells are major sources of interferon gamma (IFN-γ). Recent studies have shown that IFN-γ can inhibit EVT invasion via a mechanism dependent on an increase in EVT apoptosis and a decrease in matrix metalloproteinases (MMPs). Regarding controversies in this context, this study aimed to comprehensively review the role of IFN-γ and IFN-γ-producing cells in EVT invasion, successful pregnancy, and preeclampsia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.