Evidence map›Paper›PMID 36289117›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2023

COVID-19-associated Guillain-Barré syndrome in the early pandemic experience in Lombardia (Italy).

Filippo Martinelli-Boneschi, Antonio Colombo, Nereo Bresolin, Maria Sessa, Pietro Bassi, Giampiero Grampa, Eugenio Magni, Maurizio Versino, Carlo Ferrarese, Davide Zarcone and 32 more

Erratum issuedOpen access · hybridAbstract readMulticenter Study
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. The burden and management of emergency room neurological consultation in hub and spoke Italian hospitals: the nationwide surveys of the Italian Association for Emergency Neurology (ANEU).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  4. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

42 authors at 15 institutions in 1 country.

Filippo Martinelli-BoneschiNeurology Unit, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy. filippo.martinelli@unimi.it.ORCID http://orcid.org/0000-0002-9955-1368
Antonio ColomboMembro Direttivo Nazionale SNO, Polo Neurologico Brianteo, Seregno, MB, Italy.
Nereo BresolinNeurology Unit, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy.
Maria SessaU.O. Neurologia Ospedale Giovanni XXIII, Bergamo, Italy.
Pietro BassiU.O. Neurologia, Ospedale San Giuseppe, Milan, Italy.
Giampiero GrampaU.O. Neurologia, Ospedale Sant'Anna, Como, Italy.
Eugenio MagniU.O. NeurologiaPoliambulanza, Brescia, Italy.
Maurizio VersinoUniversità Dell' InsubriaU.O. Neurologia Ospedale Di Varese, Varese, Italy.
Carlo FerrareseUniversità Degli Studi Milano Bicocca, U.O. Neurologia, Ospedale San Gerardo, Monza, Italy.
Davide ZarconeU.O. Neurologia, Ospedale Sant'Antonio Abate, Gallarate, VA, Italy.
Alberto AlbaneseU.O. Neurologia, IRCCS Istituto Clinico Humanitas, Milan, Italy.
Giuseppe MicieliU.O. Neurologia, Fondazione Mondino, Pavia, Italy.
Carla ZanferrariU.O. Neurologia, Ospedale Vizzolo Predabissi, Vizzolo Predabissi, MI, Italy.
Antonio CagnanaU.O. Neurologia, Ospedale Maggiore, Crema, CR, Italy.
Claudio FerranteU.O. Ospedale Policlinico Ponte San Pietro, Ponte San Pietro, BG, Italy.
Angelo ZilioliU.O. NeurologiaOspedale Maggiore, Lodi, Italy.
Davide LocatelliUniversità Insubria, U.O. NeurochirurgiaOspedale Di Varese, Varese, Italy.
Maria Vittoria CalloniMembro Direttivo Nazionale SNO, Rome, Italy.
Maria Luisa DelodoviciUniversità Dell' InsubriaU.O. Neurologia Ospedale Di Varese, Varese, Italy.
Mattia PozzatoNeurology Unit, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy.
Valerio PatissoNeurology Unit, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy.
Francesco BortolanU.O. Osservatorio Epidemiologico Regionale, Struttura Epidemiologia E Valutazione Delle Performance, Milan, Regione Lombardia, Italy.
Camillo ForestiU.O. Neurologia Ospedale Giovanni XXIII, Bergamo, Italy.
Barbara FrigeniU.O. Neurologia Ospedale Giovanni XXIII, Bergamo, Italy.
Stefania CanellaU.O. Neurologia, Ospedale San Giuseppe, Milan, Italy.
Rubjona XhaniU.O. Neurologia, Ospedale Sant'Anna, Como, Italy.
Massimo CrabbioU.O. NeurologiaPoliambulanza, Brescia, Italy.
Alessandro ClemenziUniversità Dell' InsubriaU.O. Neurologia Ospedale Di Varese, Varese, Italy.
Marco MauriUniversità Dell' InsubriaU.O. Neurologia Ospedale Di Varese, Varese, Italy.
Simone BerettaUniversità Degli Studi Milano Bicocca, U.O. Neurologia, Ospedale San Gerardo, Monza, Italy.
Isidoro La SpinaU.O. Neurologia, Ospedale Sant'Antonio Abate, Gallarate, VA, Italy.
Simona BernasconiU.O. Neurologia, Ospedale Sant'Antonio Abate, Gallarate, VA, Italy.
Tiziana De SantisU.O. Neurologia, IRCCS Istituto Clinico Humanitas, Milan, Italy.
Anna CavalliniU.O. Neurologia, Fondazione Mondino, Pavia, Italy.
Michela RanieriU.O. Neurologia, Ospedale Vizzolo Predabissi, Vizzolo Predabissi, MI, Italy.
Elisabetta D'AddaU.O. Neurologia, Ospedale Maggiore, Crema, CR, Italy.
Maria Elisa FrugugliettiU.O. Neurologia, Ospedale Maggiore, Crema, CR, Italy.
Lorenzo PeverelliU.O. NeurologiaOspedale Maggiore, Lodi, Italy.
Edoardo AgostiUniversità Insubria, U.O. NeurochirurgiaOspedale Di Varese, Varese, Italy.
Olivia LeoniU.O. Osservatorio Epidemiologico Regionale, Struttura Epidemiologia E Valutazione Delle Performance, Milan, Regione Lombardia, Italy.
Andrea RigamontiU.O. Neurologia, Ospedale Manzoni, Lecco, Italy.
Andrea SalmaggiCoordinatore SNO Lombardia, U.O. Neurologia, Ospedale Manzoni, Lecco, Italy.
University of Insubria · ITUniversity of Milan · ITAzienda Ospedaliera Ospedale Maggiore · ITOspedale Papa Giovanni XXIII · ITOspedale Sant Antonio · ITAlessandro Manzoni Hospital · ITAssociazione Regionale Allevatori della Lombardia · ITASST Melegnano e della Martesana · ITFondazione Poliambulanza Istituto Ospedaliero · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITOspedale Maggiore · ITOspedale San Giuseppe · ITOspedale Sant'Anna · ITUniversity of Milano-Bicocca · ITOspedale San Pietro Fatebenefratelli · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo estimate the incidence and describe clinical characteristics and outcome of GBS in COVID-19 patients (COVID19-GBS) in one of the most hit regions during the first pandemic wave, Lombardia.

methodsAdult patients admitted to 20 Neurological Units between 1/3-30/4/2020 with COVID19-GBS were included as part of a multi-center study organized by the Italian society of Hospital Neuroscience (SNO).

resultsThirty-eight COVID19-GBS patients had a mean age of 60.7 years and male frequency of 86.8%. CSF albuminocytological dissociation was detected in 71.4%, and PCR for SARS-CoV-2 was negative in 19 tested patients. Based on neurophysiology, 81.8% of patients had a diagnosis of AIDP, 12.1% of AMSAN, and 6.1% of AMAN. The course was favorable in 76.3% of patients, stable in 10.5%, while 13.2% worsened, of which 3 died. The estimated occurrence rate in Lombardia ranges from 0.5 to 0.05 GBS cases per 1000 COVID-19 infections depending on whether you consider positive cases or estimated seropositive cases. When we compared GBS cases with the pre-pandemic period, we found a reduction of cases from 165 to 135 cases in the 2-month study period in Lombardia.

conclusionsWe detected an increased incidence of GBS in COVID-19 patients which can reflect a higher risk of GBS in COVID-19 patients and a reduction of GBS events during the pandemic period possibly due to a lower spread of more common respiratory infectious diseases determined by an increased use of preventive measures.

Indexed as

COVID-19Guillain-Barre SyndromeAdultHumansItalyMaleMiddle AgedPandemicsSARS-CoV-2Coronavirus infectionsCOVID-19Guillain-Barré syndromeSARS-CoV-2 infection

Identifiers

PMID36289117
PMCPMC9607708
OpenAlexW4307572275

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.