Evidence map›Paper›PMID 36288929›Full record

ArticleExperimental animals2023

RNA-Seq analysis of obese Pdha1

Zhaohong Geng, Yuchan Yuan, Dan He, Hewang Lee, Hongyan Wang, Nan Niu, Zhigang Ni, Shopit Abdullah, Zeyao Tang, Peng Qu

Open access · diamondAbstract read
In one paragraph

Article in Experimental animals, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Zhaohong GengDepartment of Cardiology, Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Road, Dalian 116000, P.R. China.
Yuchan YuanDepartment of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.
Dan HeDepartment of Cardiology, Peking University People's Hospital, No. 11, Xizhimen South Street, Xicheng District, Beijing, 100044, P.R. China.
Hewang LeeKidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
Hongyan WangDepartment of Cardiology, Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Road, Dalian 116000, P.R. China.
Nan NiuDepartment of Cardiology, Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Road, Dalian 116000, P.R. China.
Zhigang NiDepartment of Cardiology, Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Road, Dalian 116000, P.R. China.
Shopit AbdullahAcademic Integrated Medicine & College of Pharmacy, Department of Pharmacology, Dalian Medical University, No. 9 West Section Lvshun South Road, Dalian 116044, P.R. China.
Zeyao TangAcademic Integrated Medicine & College of Pharmacy, Department of Pharmacology, Dalian Medical University, No. 9 West Section Lvshun South Road, Dalian 116044, P.R. China.
Peng QuDepartment of Cardiology, Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Road, Dalian 116000, P.R. China.
Dalian Medical University · CNNational Institutes of Health · USPeking University People's Hospital · CNSecond Affiliated Hospital of Dalian Medical University · CNXinHua Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyruvate dehydrogenase complex (PDH) is an important complex of three enzymes that transforms pyruvate into acetyl-CoA, subsequently entering the tricarboxylic acid (TCA) cycle to produce ATP and electron donors. As a key regulator of energy and metabolic homeostasis, PDH is considered a potential therapeutic target of many diseases. On the other hand, the relationship between PDH and obesity is not clear. In this study, peripheral blood of Pdha1

Indexed as

Diet, High-FatObesityAnimalsIntegrasesMiceMice, Inbred C57BLRNA-SeqTranscriptomeCre recombinaseIntegrasesknockout miceobesityPdha1RNA-seq

Identifiers

PMID36288929
PMCPMC9978130
OpenAlexW4307430008

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.