ArticleBMJ open2022
Fetal-neonatal and maternal pregnancy outcomes in women with rheumatoid arthritis: a population-based cohort study.
Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Association between disease activity of rheumatoid arthritis and maternal and fetal outcomes in pregnant women: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2023Pooled it
- Fertility and Birth Outcomes in Rheumatoid Arthritis: A Narrative Review.Rheumatology and therapy · 2026Review
- Maternal systemic autoimmune rheumatic diseases and childhood mental disorders: a nationwide cohort study.Lupus science & medicine · 2026Article
- Article
- Analysis of inflammatory immune correlation of the coagulation spectrum, PT, FBG, FDP, D-D in autoimmune diseases.Journal of medical biochemistry · 2026Article
- Review
- Impact of Rheumatoid Arthritis on Pregnancy Outcomes: Increased Risks of Abortion and Low Birth Weight in a Prospective Case-Control Study.Mediterranean journal of rheumatology · 2025Article
- Maternal and neonatal outcomes in pregnancies with rheumatoid arthritis, psoriatic arthritis, and spondyloarthritis: a comparative study.BMC rheumatology · 2025Article
- Immune Dysregulation at the Maternal-Fetal Interface Exacerbates Adverse Pregnancy Outcomes in an Inflammatory Arthritis Murine Model.Biomedicines · 2025Article
- Family Planning and Rheumatoid Arthritis.Current rheumatology reports · 2025Review
- A Cohort Study of Pregnancy and Fetal Complications Among Patients with Rheumatologic Disorders.Journal of obstetrics and gynaecology of India · 2025Article
- Rheumatoid arthritis-associated complications during pregnancy and its effect on offspring: comprehensive review.Inflammopharmacology · 2024Review
- Rheumatoid arthritis and adverse pregnancy outcomes: a bidirectional two-sample mendelian randomization study.BMC pregnancy and childbirth · 2024Article
- Maternal cardiovascular events in autoimmune rheumatic diseases and antiphospholipid syndrome pregnancies.American journal of obstetrics & gynecology MFM · 2024Article
- Pregnancy outcomes in women with rheumatoid arthritis: an 11-year French nationwide study.RMD open · 2024Article
- Pregnancy outcomes in juvenile idiopathic arthritis: systematic review and meta-analysis.Proceedings (Baylor University. Medical Center)Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesRheumatoid arthritis (RA) may adversely influence pregnancy and lead to adverse birth outcomes. This study estimated the risk of adverse fetal-neonatal and maternal pregnancy outcomes in women with RA.
designThis was a retrospective cohort study.
settingWe used both the National Health Insurance database and the Taiwan Birth Reporting System, between 2004 and 2014.
participantsWe identified 2 100 143 singleton pregnancies with 922 RA pregnancies, either live births or stillbirths, delivered by 1 468 318 women. OUTCOME MEASURES: ORs with 95% CIs for fetal-neonatal and maternal outcomes were compared between pregnancies involving mothers with and without RA using an adjusted generalised estimating equation model.
resultsCovariates including age, infant sex, Charlson Comorbidity Index, urbanisation, income, occupation, birth year and maternal nationality were adjusted. Compared with pregnancies in women without RA, pregnancies in women with RA showed that the fetuses/neonates had adjusted ORs (95% CI) of 2.03 (1.66 to 2.50) for low birth weight (n=123), 1.99 (1.64 to 2.40) for prematurity (n=141), 1.77 (1.46 to 2.15) for small for gestational age (n=144) and 1.35 (1.03 to 1.78) for fetal distress (n=60). Pregnancies in women with RA had adjusted ORs (95% CI) of 1.24 (1.00 to 1.52) for antepartum haemorrhage (n=106), 1.32 (1.15 to 1.51) for caesarean delivery (n=398), and 3.33 (1.07 to 10.34) for disseminated intravascular coagulation (n=3), compared with women without RA. Fetuses/neonates born to mothers with RA did not have a higher risk of being stillborn or having fetal abnormalities. Pregnant women with RA did not have increased risks of postpartum death, cardiovascular complications, surgical complications or systemic organ dysfunction.
conclusionsPregnancies in women with RA were associated with higher risks of multiple adverse fetal-neonatal and maternal outcomes; however, most pregnancies in these women were successful.
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