Evidence map›Paper›PMID 36288695›Full record

ArticleCell reports2022

tRNA methylation resolves codon usage bias at the limit of cell viability.

Isao Masuda, Yuka Yamaki, Rajesh Detroja, Somnath Tagore, Henry Moore, Sunita Maharjan, Yuko Nakano, Thomas Christian, Ryuma Matsubara, Todd M Lowe and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Compendium of RNA modifications for bacterial stress adaptation.Microbiology and molecular biology reviews : MMBR · 2026
    Review
  2. Nicotinamide-Based Covalent Inhibitors of tRNA (mACS medicinal chemistry letters · 2026
    Article
  3. The NAT10/c-Myc positive feedback loop orchestrates tRNA acCellular & molecular biology letters · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. NSUN2-tRNACellular & molecular biology letters · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. A tRNA modification inbioRxiv : the preprint server for biology · 2023
    Article
  17. tRNAs at the Virus-Host Interface.Wiley interdisciplinary reviews. RNA
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Isao MasudaDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Yuka YamakiDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Rajesh DetrojaThe Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Somnath TagoreThe Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel; Department of Systems Biology, Columbia University Medical Center, Herbert Irving Cancer Research Center, New York, NY, USA.
Henry MooreDepartment of Biomolecular Engineering, Baskin School of Engineering, University of California Santa Cruz, Santa Cruz, CA, USA; UCSC Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA.
Sunita MaharjanDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Yuko NakanoDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Thomas ChristianDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Ryuma MatsubaraDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA; Institute of Cell Biology, University of Bern, Bern, Switzerland.
Todd M LoweDepartment of Biomolecular Engineering, Baskin School of Engineering, University of California Santa Cruz, Santa Cruz, CA, USA; UCSC Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA.
Milana Frenkel-MorgensternThe Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Ya-Ming HouDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address: ya-ming.hou@jefferson.edu.
Thomas Jefferson University · USBar-Ilan University · ILUniversity of California, Santa Cruz · USUniversity of Bern · CH

Funding

tRNA in codon usageR35GM134931 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI HOU, YA-MING · 2020 to 2025
$5.4M
A Unified Atlas of Dynamic tRNA FunctionR01HG006753 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI LOWE, TODD MICHAEL · 2012 to 2022
$4.6M
TrmD-targeting actinobacterial natural products as next generation antibioticsR01AI164490 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI HOU, YA-MING, SHEN, BEN · 2021 to 2025
$4.2M
Discovery of Gram-negative permeable chemical probes for tRNA methylationR01AI139202 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI HOU, YA-MING · 2019 to 2022
$2.4M
NHGRI NIH HHS R01 HG006753NIAID NIH HHS R01 AI139202NIAID NIH HHS R01 AI164490NIGMS NIH HHS R35 GM134931
6 · The paper itself

Abstract

Codon usage of each genome is closely correlated with the abundance of tRNA isoacceptors. How codon usage bias is resolved by tRNA post-transcriptional modifications is largely unknown. Here we demonstrate that the N

Indexed as

AnticodonCodon UsageCell SurvivalCodonEscherichia coliGuanosineMethylationProlineRNA, TransferAnticodonCodonGuanosineProlineRNA, Transferaminoacylation with prolinecmo(5)U34CP: MicrobiologyCP: Molecular biologyESKAPEm(1)G37-tRNAPro codons CC[C/U]Pro(GGG)proSPro(UGG)suppressor screensTrmD

Identifiers

PMID36288695
PMCPMC9643105
OpenAlexW4307905183

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.