Evidence map›Paper›PMID 36288662›Full record

ArticleHearing research2022

Loss of the chromatin remodeler CHD7 impacts glial cells and myelination in the mouse cochlear spiral ganglion.

K Elaine Ritter, Sloane M Lynch, Ashley M Gorris, Lisa A Beyer, Lisa Kabara, David F Dolan, Yehoash Raphael, Donna M Martin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hearing research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. CHD7 and SOX2 act in a common gene regulatory network during mammalian semicircular canal and cochlear development.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  2. Article
  3. DigenicHeliyon · 2024
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

K Elaine RitterDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.
Sloane M LynchCollege of Literature, Science and Art, University of Michigan, Ann Arbor, MI, USA.
Ashley M GorrisCollege of Literature, Science and Art, University of Michigan, Ann Arbor, MI, USA.
Lisa A BeyerDepartment of Otolaryngology - Head and Neck Surgery, University of Medical School, Ann Arbor, MI, USA.
Lisa KabaraDepartment of Otolaryngology - Head and Neck Surgery, University of Medical School, Ann Arbor, MI, USA.
David F DolanDepartment of Otolaryngology - Head and Neck Surgery, University of Medical School, Ann Arbor, MI, USA.
Yehoash RaphaelDepartment of Otolaryngology - Head and Neck Surgery, University of Medical School, Ann Arbor, MI, USA.
Donna M MartinDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: donnamm@med.umich.edu.
University of Michigan–Ann Arbor · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
Sensory Mechanisms and Disorders - Administrative SupplementT32DC000011 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Michael Thomas Roberts · 1989 to 2026
$9.5M
Epigenetics of Inner ear neurosensory cell developmentR01DC018404 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KWAN, KELVIN Y., MARTIN, DONNA M. · 2020 to 2024
$2.7M
Exploration of Connexin26 Genotypes, Phenotypes, and Gene ReplacementR01DC014456 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARTIN, DONNA M., RAPHAEL, YEHOASH · 2016 to 2020
$2.5M
NCI NIH HHS P30 CA046592NIDCD NIH HHS R01 DC014456NIDCD NIH HHS R01 DC018404NIDCD NIH HHS T32 DC000011
6 · The paper itself

Abstract

CHARGE syndrome is a multiple anomaly developmental disorder characterized by a variety of sensory deficits, including sensorineural hearing loss of unknown etiology. Most cases of CHARGE are caused by heterozygous pathogenic variants in CHD7, the gene encoding Chromodomain DNA-binding Protein 7 (CHD7), a chromatin remodeler important for the development of neurons and glial cells. Previous studies in the Chd7

Indexed as

CHARGE SyndromeEar, InnerAnimalsChromatinDNA-Binding ProteinsMiceNeurogliaSpiral GanglionChd7 protein, mouseChromatinDNA-Binding ProteinsABRCHARGE syndromeHearingMyelinSatellite glial cellSchwann cell

Identifiers

PMID36288662
PMCPMC10184650
OpenAlexW4304944443

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.