ArticleArteriosclerosis, thrombosis, and vascular biology2022
Impairment of Endothelial Function by Cigarette Smoke Is Not Caused by a Specific Smoke Constituent, but by Vagal Input From the Airway.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Tobacco and marijuana induce adverse effects on cardiac function and platelet activity and reduce tissue preservation following myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2026Article
- Nicotine-containing products and the cardiovascular system: mechanisms and global health implications.Nature reviews. Cardiology · 2026Review
- Association of PM2.5 exposure with 10-year atherosclerotic cardiovascular disease risk: a mediation analysis of blood and urinary biomarkers.Frontiers in public health · 2026Article
- Chronic Pod-Mod E-Cigarette Aerosol Exposure Induces Aortic Dysfunction in Hypercholesterolemic Mice: Role of Oxidative Stress and Inflammation.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Exposure to Toxic Compounds Using Alternative Smoking Products: Analysis of Empirical Data.International journal of environmental research and public health · 2025Article
- Role of the Transient Receptor Potential Ankyrin-1 in the Pulmonary, Vascular, and Systemic Effects of Short-Term Acrolein Inhalation in Mice: Implications for the Toxicity of Electronic Nicotine Delivery Systems.Cardiovascular toxicology · 2025Article
- Almost 20 years have passed: a view of heated tobacco and vape.European heart journal supplements : journal of the European Society of Cardiology · 2025Article
- Pregnancy and Postpartum Effects of Electronic Cigarettes on Maternal Health and Vascular Function in the Fourth Trimester.Cardiovascular toxicology · 2025Article
- Vaping causes an acute BMI-dependent change in pulmonary blood flow.Physiological reports · 2024Article
- Formaldehyde and the transient receptor potential ankyrin-1 contribute to electronic cigarette aerosol-induced endothelial dysfunction in mice.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Influence of gestational window on offspring vascular health in rodents with in utero exposure to electronic cigarettes.The Journal of physiology · 2024Article
- Addressing Cardiovascular Toxicity Risk of Electronic Nicotine Delivery Systems in the Twenty-First Century: "What Are the Tools Needed for the Job?" and "Do We Have Them?"Cardiovascular toxicology · 2024Review
- Review
- Acute myocardial infarction with e-cigarette or vaping-use associated lung injury in a young Filipino vape user.Respirology case reports · 2024Article
- Impairment of Endothelial Function by Aerosol From Marijuana Leaf Vaporizers.Journal of the American Heart Association · 2023Article
- Impairment of Endothelial Function by Cigarette Smoke and e-Cigarette Aerosol Requires RAGE.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- Electronic Cigarette Harms: Aggregate Evidence Shows Damage to Biological Systems.International journal of environmental research and public health · 2023Review
- Varied effects of tobacco smoke and e-cigarette vapor suggest that nicotine does not affect endothelium-dependent relaxation and nitric oxide signaling.Scientific reports · 2023Article
- Effects of electronic cigarette E-liquid and device wattage on vascular function.Toxicology and applied pharmacology · 2023Article
- Regulation of endothelial function by cigarette smoke and next-generation tobacco and nicotine products.Pflugers Archiv : European journal of physiology · 2023Review
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundExposure to tobacco or marijuana smoke, or e-cigarette aerosols, causes vascular endothelial dysfunction in humans and rats. We aimed to determine what constituent, or class of constituents, of smoke is responsible for endothelial functional impairment.
methodsWe investigated several smoke constituents that we hypothesized to mediate this effect by exposing rats and measuring arterial flow-mediated dilation (FMD) pre- and post-exposure. We measured FMD before and after inhalation of sidestream smoke from research cigarettes containing normal and reduced nicotine level with and without menthol, as well as 2 of the main aldehyde gases found in both smoke and e-cigarette aerosol (acrolein and acetaldehyde), and inert carbon nanoparticles.
resultsFMD was reduced by all 4 kinds of research cigarettes, with extent of reduction ranging from 20% to 46% depending on the cigarette type. While nicotine was not required for the impairment, higher nicotine levels in smoke were associated with a greater percent reduction of FMD (41.1±4.5% reduction versus 19.2±9.5%;
conclusionsThere is no single constituent or class of constituents responsible for acute impairment of endothelial function by smoke; rather, we propose that acute endothelial dysfunction by disparate inhaled products is caused by vagus nerve signaling initiated by airway irritation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.