ArticleScience translational medicine2022
Therapeutic gene editing of T cells to correct CTLA-4 insufficiency.
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- DAMP signaling networks: from receptors to diverse pathophysiological functions.Journal of advanced research · 2026Review
- Targeted Epigenetic Activation ofBiomedicines · 2026Article
- CRISPR-Cas9-based gene editing as a proof-of-concept approach in an inborn error of immunity caused by a DCLRE1C variant.Immunologic research · 2026Article
- Appraisal of CRISPR Technology as an Innovative Screening to Therapeutic Toolkit for Genetic Disorders.Molecular biotechnology · 2026Review
- Inborn errors of regulatory T-cell differentiation and function.The Journal of allergy and clinical immunology · 2025Review
- Precision T cell correction platform for inborn errors of immunity.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Dissection of the trans-endocytosis and signal inhibition functions of CTLA-4 through the study of a disease-associated Y139C mutation.Cellular & molecular immunology · 2025Article
- Gene therapy for inborn errors of immunity: past progress, current status and future directions.Rare disease and orphan drugs journal · 2025Article
- Pattern recognition receptors: function, regulation and therapeutic potential.Signal transduction and targeted therapy · 2025Review
- Therapeutic Potential of CRISPR/Cas in Hashimoto's Thyroiditis: A Comprehensive Review.Current gene therapy · 2024Review
- The expression of CTLA-4 in hepatic alveolar echinococcosis patients and blocking CTLA-4 to reverse T cell exhaustion inFrontiers in immunology · 2024Article
- From mechanism to therapy: the journey of CD24 in cancer.Frontiers in immunology · 2024Review
- Non-canonical NFKB signaling endows suppressive function through FOXP3-dependent regulatory T cell program.Heliyon · 2023Article
- Lipid nanoparticles allow efficient and harmless ex vivo gene editing of human hematopoietic cells.Blood · 2023Article
- Gene therapy for inborn errors of immunity: past, present and future.Nature reviews. Immunology · 2023Review
- CRISPR-based mFrontiers in cell and developmental biology · 2023Review
- Too much of a good thing: a review of primary immune regulatory disorders.Frontiers in immunology · 2023Review
- Immune Checkpoint Inhibitor-Based Combination Therapy for Colorectal Cancer: An Overview.International journal of general medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 6 institutions in 2 countries.
Thomas Andrew FoxUCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.ORCID 0000-0002-1163-2295
Benjamin Christopher HoughtonUCL Great Ormond Street Institute of Child Health, UCL, London WC1N 1EH, UK.ORCID 0000-0002-5378-8749
Lina PetersoneUCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.ORCID 0000-0001-8571-9185
Erin WatersUCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.ORCID 0000-0003-3431-9063
Natalie Mona EdnerUCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.ORCID 0000-0003-2799-2890
Alex McKennaUCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.
Olivier PrehamUCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.ORCID 0000-0001-8795-1391
Claudia HinzeUCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.ORCID 0000-0002-8029-842X
Cayman WilliamsUCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.ORCID 0000-0002-0518-1379
Adriana Silva de AlbuquerqueUCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.ORCID 0000-0003-3391-0396
Alan KennedyUCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.ORCID 0000-0003-0384-3866
Anne Maria PesenackerUCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.ORCID 0000-0002-7968-0277
Pietro GenoveseDana-Farber/Boston Children's Cancer and Blood Disorder Center, Boston, MA 02115, USA.ORCID 0000-0001-9507-9003
Lucy Sarah Kate WalkerUCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.ORCID 0000-0001-5986-5015
Siobhan Oisin BurnsUCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.ORCID 0000-0002-3356-9506
David Michael SansomUCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.ORCID 0000-0001-6506-3115
Claire BoothUCL Great Ormond Street Institute of Child Health, UCL, London WC1N 1EH, UK.ORCID 0000-0002-2626-5037
Emma Catherine MorrisUCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.ORCID 0000-0003-4834-1130
University College London · GBGreat Ormond Street Hospital · GBUniversity College London Hospitals NHS Foundation Trust · GBDana-Farber/Boston Children's Cancer and Blood Disorders Center · USNational Institute for Health Research · GBRoyal Free London NHS Foundation Trust · GB
Funding
Department of HealthMedical Research Council MR/N001435/1Versus Arthritis 21147Versus Arthritis 21738Wellcome Trust 204798Wellcome Trust 204798/Z/16/ZWellcome Trust 216358/Z/19/Z
Abstract
Heterozygous mutations in
Indexed as
Lymphocyte ActivationT-LymphocytesAnimalsAntigens, CDB7-1 AntigenB7-2 AntigenCTLA-4 AntigenDNA, ComplementaryGene EditingHumansMiceAntigens, CDB7-1 AntigenB7-2 AntigenCTLA-4 AntigenDNA, Complementary
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.