Evidence map›Paper›PMID 36288139›Full record

ArticleVeterinary sciences2022

Toothed Whales Have Black Neurons in the Blue Spot.

Simona Sacchini, Antonio Fernández, Blanca Mompeó, Raquel Ramírez, Manuel Arbelo, Unn Holgersen, Oscar Quesada-Canales, Ayoze Castro-Alonso, Marisa Andrada

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The neuromodulatory fragility hypothesis of Alzheimer's disease pathogenesis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Simona SacchiniVeterinary Histology and Pathology, Veterinary School, Institute of Animal Health, University of Las Palmas de Gran Canaria, c/Transmontaña s/n, 35416 Arucas, Spain.ORCID 0000-0001-6493-1275
Antonio FernándezVeterinary Histology and Pathology, Veterinary School, Institute of Animal Health, University of Las Palmas de Gran Canaria, c/Transmontaña s/n, 35416 Arucas, Spain.ORCID 0000-0001-5281-0521
Blanca MompeóDepartment of Morphology, Campus Universitario de San Cristobal, University of Las Palmas de Gran Canaria, c/Blas Cabrera Felipe s/n, 35016 Las Palmas de Gran Canaria, Spain.
Raquel RamírezDepartment of Morphology, Campus Universitario de San Cristobal, University of Las Palmas de Gran Canaria, c/Blas Cabrera Felipe s/n, 35016 Las Palmas de Gran Canaria, Spain.
Manuel ArbeloVeterinary Histology and Pathology, Veterinary School, Institute of Animal Health, University of Las Palmas de Gran Canaria, c/Transmontaña s/n, 35416 Arucas, Spain.ORCID 0000-0002-1623-5010
Unn HolgersenNordland Research Institute, P.O. Box 1490, 8049 Bodø, Norway.ORCID 0000-0002-5666-459X
Oscar Quesada-CanalesVeterinary Histology and Pathology, Veterinary School, Institute of Animal Health, University of Las Palmas de Gran Canaria, c/Transmontaña s/n, 35416 Arucas, Spain.ORCID 0000-0002-2365-351X
Ayoze Castro-AlonsoVeterinary Histology and Pathology, Veterinary School, Institute of Animal Health, University of Las Palmas de Gran Canaria, c/Transmontaña s/n, 35416 Arucas, Spain.
Marisa AndradaVeterinary Histology and Pathology, Veterinary School, Institute of Animal Health, University of Las Palmas de Gran Canaria, c/Transmontaña s/n, 35416 Arucas, Spain.ORCID 0000-0002-2411-9714

Funding

Ministerio de Ciencia, Innovación y Universidades PGC2018-101226-B-I00Ministerio de Economía y Competitividad CGL2015-71498-P
6 · The paper itself

Abstract

Neuromelanin (NM) is a dark polymer pigment that is located mostly in the human substantia nigra, and in the locus ceruleus, referred to as "the blue spot". NM increases linearly with age, and has been described mainly in the human brain; however, it also occurs in the neurons of monkeys, horses, giraffes, cattle, sheep, goats, dogs, rats, and even in frogs. While in most of these mammals NM shows the histochemical and ultrastructural features typical of lipofuscins, human NM is confined within cytoplasmic organelles that are surrounded by a double membrane, suggesting an autophagic origin. In a study on the morphology of the locus ceruleus of the family

Indexed as

agingbeaked whalescetaceansdolphinslocus ceruleusneurodegenerationneuromelanin

Identifiers

PMID36288139
PMCPMC9610827

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.