Evidence map›Paper›PMID 36287961›Full record

ArticleToxins2022

Quantitative Proteomic Analysis of Zearalenone Exposure on Uterine Development in Weaned Gilts.

Xinglin Liu, Zengchun Wang, Yanping Jiang, Libo Huang, Xuejun Yuan, Yang Li, Ning Jiao, Weiren Yang, Shuzhen Jiang

Open access · goldAbstract readRandomized Controlled Trial, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xinglin LiuColloge of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, No. 61 Daizong Street, Tai'an 271018, China.ORCID 0000-0001-6681-2640
Zengchun WangShandong Muge Animal Husbandry Equipment Co., Ltd., Yucheng 251200, China.
Yanping JiangZhongcheng Feed Technology Co., Ltd., Feicheng 271600, China.
Libo HuangColloge of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, No. 61 Daizong Street, Tai'an 271018, China.
Xuejun YuanDepartment of Life Sciences, Shandong Agricultural University, No. 61 Daizong Street, Tai'an 271018, China.ORCID 0000-0002-7028-6732
Yang LiColloge of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, No. 61 Daizong Street, Tai'an 271018, China.ORCID 0000-0002-6042-1259
Ning JiaoColloge of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, No. 61 Daizong Street, Tai'an 271018, China.
Weiren YangColloge of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, No. 61 Daizong Street, Tai'an 271018, China.
Shuzhen JiangColloge of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, No. 61 Daizong Street, Tai'an 271018, China.
Shandong Agricultural University · CNShandong Province Animal Husbandry and Veterinary Bureau · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to explore the effect of zearalenone (ZEA) exposure on uterine development in weaned gilts by quantitative proteome analysis with tandem mass spectrometry tags (TMT). A total of 16 healthy weaned gilts were randomly divided into control (basal diet) and ZEA3.0 treatments groups (basal diet supplemented with 3.0 mg/kg ZEA). Results showed that vulva size and uterine development index were increased (p < 0.05), whereas serum follicle stimulation hormone, luteinizing hormone and gonadotropin-releasing hormone were decreased in gilts fed the ZEA diet (p < 0.05). ZEA, α-zearalenol (α-ZOL) and β-zearalenol (β-ZOL) were detected in the uteri of gilts fed a 3.0 mg/kg ZEA diet (p < 0.05). The relative protein expression levels of creatine kinase M-type (CKM), atriopeptidase (MME) and myeloperoxidase (MPO) were up-regulated (p < 0.05), whereas aldehyde dehydrogenase 1 family member (ALDH1A2), secretogranin-1 (CHGB) and SURP and G-patch domain containing 1 (SUGP1) were down-regulated (p < 0.05) in the ZEA3.0 group by western blot, which indicated that the proteomics data were dependable. In addition, the functions of differentially expressed proteins (DEPs) mainly involved the cellular process, biological regulation and metabolic process in the biological process category. Some important signaling pathways were changed in the ZEA3.0 group, such as extracellular matrix (ECM)-receptor interaction, focal adhesion and the phosphoinositide 3-kinase−protein kinase B (PI3K-AKT) signaling pathway (p < 0.01). This study sheds new light on the molecular mechanism of ZEA in the uterine development of gilts.

Indexed as

ZearalenoneAldehyde Dehydrogenase 1 FamilyAnimalsChromograninsCreatine KinaseFemaleGonadotropin-Releasing HormoneLuteinizing HormoneNeprilysinPeroxidasePhosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesProteomeProteomicsProto-Oncogene Proteins c-aktSus scrofaAldehyde Dehydrogenase 1 FamilyChromograninsCreatine KinaseGonadotropin-Releasing HormoneLuteinizing HormoneNeprilysinPeroxidasePhosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesProteomeProto-Oncogene Proteins c-aktzearalenolZearalenoneZeranolgiltsproteomicserum hormonesuterine developmentzearalenone

Identifiers

PMID36287961
PMCPMC9610722
OpenAlexW4304187080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.