Evidence map›Paper›PMID 36287944›Full record

ArticleToxins2022

The Short-Term Impact of Botulinum Neurotoxin-A on Muscle Morphology and Gait in Children with Spastic Cerebral Palsy.

Nicky Peeters, Eirini Papageorgiou, Britta Hanssen, Nathalie De Beukelaer, Lauraine Staut, Marc Degelaen, Christine Van den Broeck, Patrick Calders, Hilde Feys, Anja Van Campenhout and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Toxins, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05126693 (Algorithms for Patient-specific Treatment Planning in Cerebral Palsy Based on the Muscle and Tendon Architecture - Short Term Follow-up of a Botulinum Toxin Intervention in Children With Spastic Cerebral Palsy), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05126693 nacompletednot on this map

Algorithms for Patient-specific Treatment Planning in Cerebral Palsy Based on the Muscle and Tendon Architecture - Short Term Follow-up of a Botulinum Toxin Intervention in Children With Spastic Cerebral Palsy

TypeinterventionalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2020 to 2022Enrolled61ConditionsSpastic Cerebral PalsyArmsBotulinum Toxin treatment combined with a post-BoNT intensive physical therapy period guided by individualized treatment goals.
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Nicky PeetersDepartment of Rehabilitation Sciences, KU Leuven, 3001 Leuven, Belgium.ORCID 0000-0003-0380-9174
Eirini PapageorgiouDepartment of Rehabilitation Sciences, KU Leuven, 3001 Leuven, Belgium.
Britta HanssenDepartment of Rehabilitation Sciences, KU Leuven, 3001 Leuven, Belgium.ORCID 0000-0003-0406-6050
Nathalie De BeukelaerDepartment of Rehabilitation Sciences, KU Leuven, 3001 Leuven, Belgium.ORCID 0000-0002-7800-3354
Lauraine StautDepartment of Rehabilitation Sciences, KU Leuven, 3001 Leuven, Belgium.
Marc DegelaenInkendaal Rehabilitation Hospital, 1602 Vlezenbeek, Belgium.ORCID 0000-0001-6651-2496
Christine Van den BroeckDepartment of Rehabilitation Sciences, Ghent University, 9000 Ghent, Belgium.
Patrick CaldersDepartment of Rehabilitation Sciences, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0001-6327-8155
Hilde FeysDepartment of Rehabilitation Sciences, KU Leuven, 3001 Leuven, Belgium.
Anja Van CampenhoutDepartment of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-8158-5535
Kaat DesloovereDepartment of Rehabilitation Sciences, KU Leuven, 3001 Leuven, Belgium.
KU Leuven · BEGhent University · BEVrije Universiteit Brussel · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Children with spastic cerebral palsy (SCP) are often treated with intramuscular Botulinum Neurotoxin type-A (BoNT-A). Recent studies demonstrated BoNT-A-induced muscle atrophy and variable effects on gait pathology. This group-matched controlled study in children with SCP compared changes in muscle morphology 8-10 weeks post-BoNT-A treatment (

Indexed as

Botulinum Toxins, Type ACerebral PalsyNeuromuscular AgentsChildGaitHumansInjections, IntramuscularMuscle, SkeletalMuscle SpasticityTreatment OutcomeBotulinum Toxins, Type ANeuromuscular Agentsbotulinum neurotoxin type-Agaitmuscle morphologyspastic cerebral palsytreatmentultrasound

Identifiers

PMID36287944
PMCPMC9607504
OpenAlexW4298145344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.