Effect of Heating Temperature on Ammonia Emission in the Mainstream Aerosols from Heated Tobacco Products.

Heated tobacco products are devices that deliver nicotine into the body via inhalation of the mainstream aerosols generated during direct and/or indirect heating of tobacco leaf material. Ammonia in aerosols potentially increases the alkalinity and, therefore, the proportion of free nicotine for easy absorption. Meanwhile, ammonia can be a cause of adverse health effects when involved in the aerosols. This study aimed to grasp the emission behaviour of ammonia in the mainstream aerosols generated from four kinds of devices that employ different heating temperatures from 40 to 350 °C. The aerosols were generated by a vaping machine following the CRM 81 puffing protocol. Ammonia in the forms of gas and particles was trapped in 5 mM oxalic acid and subsequently determined by ion chromatography. The results showed that the total emission amount of ammonia increased with an increase in the heating temperature regardless of the device used. The gas-particle distribution of ammonia also depended on the heating temperature; gaseous ammonia was only found in the device with 40 °C of the heating temperature. These results show that ammonia in the mainstream aerosols was emitted from a common thermal process, probably thermal extraction in water vapour from a tobacco leaf.