SynthesisPharmacoEconomics2023
Health-Related Quality-of-Life Outcomes of Very Preterm or Very Low Birth Weight Adults: Evidence From an Individual Participant Data Meta-Analysis.
Synthesis in PharmacoEconomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Socioeconomic outcomes in very preterm/very low birth weight adults: individual participant data meta-analysis.Pediatric research · 2025Pooled it
- Cervical Pessary Versus Vaginal Progesterone to Prevent Preterm Birth in Women with a Singleton Pregnancy and a Short Cervix: A Systematic Review and Meta-Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2025Pooled it
- Sex differences in the effects of prematurity and/or low birthweight on neurodevelopmental outcomes: systematic review and meta-analyses.Biology of sex differences · 2023Pooled it
- Comparative evaluation of the health utilities index mark 3 and the short form 6D: evidence from an individual participant data meta-analysis of very preterm and very low birthweight adults.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Pooled it
- Cervical pessary for preventing preterm birth in singleton pregnancies.The Cochrane database of systematic reviews · 2022Pooled it
- Parent-reported quality of life at school age among children born extremely preterm is associated with non-medical determinants of health and developmental outcomes.Early human development · 2026Article
- Modeling Oxygen Saturation Targets, Mortality, and Retinopathy Among Extremely Preterm Infants.JAMA network open · 2026Article
- Severe neonatal complications and long-term health-related quality of life in very preterm and/or very low birth weight survivors: evidence from the Dutch Project on preterm and small for gestational age cohort.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Coping experiences in child and adolescent rehabilitation through a novel device: A multi-method feasibility study.Journal of pediatric rehabilitation medicine · 2026Review
- The long-term effect of very preterm birth on school readiness: exploring preschool mediating pathways.Pediatric research · 2026Article
- Self-reported positive health outcomes during the COVID-19 pandemic among adolescents born preterm in the ECHO cohort.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Lived experience of spontaneous preterm birth following spontaneous preterm labor: the primary caregiver's perspective.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- The impact of very preterm vs very low birth weight on early and mid-adulthood preference-based HRQoL outcomes: findings from the Dutch study on preterm and small for gestational age infants.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Health-Related Quality of Life in Japanese Youth Born Extremely Low-Birthweight: Impact of Attention Deficit Hyperactivity Disorder.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Article
- Health-related quality of life in children and adolescents born very preterm and its correlates: a cross-sectional study.BMJ paediatrics open · 2024Observational
- The Ethics and Practice of Periviability Care.Children (Basel, Switzerland) · 2024Article
- Psychometric Performance of Generic Childhood Multi-Attribute Utility Instruments in Preterm and Low Birthweight Populations: A Systematic Review.Children (Basel, Switzerland) · 2023Review
Corrections and comments
- Erratum issued
Authors and funding
20 authors.
Funding
Abstract
BACKGROUND AND
objectiveAssessment of health-related quality of life for individuals born very preterm and/or low birthweight (VP/VLBW) offers valuable complementary information alongside biomedical assessments. However, the impact of VP/VLBW status on health-related quality of life in adulthood is inconclusive. The objective of this study was to examine associations between VP/VLBW status and preference-based health-related quality-of-life outcomes in early adulthood.
methodsIndividual participant data were obtained from five prospective cohorts of individuals born VP/VLBW and controls contributing to the 'Research on European Children and Adults Born Preterm' Consortium. The combined dataset included over 2100 adult VP/VLBW survivors with an age range of 18-29 years. The main exposure was defined as birth before 32 weeks' gestation (VP) and/or birth weight below 1500 g (VLBW). Outcome measures included multi-attribute utility scores generated by the Health Utilities Index Mark 3 and the Short Form 6D. Data were analysed using generalised linear mixed models in a one-step approach using fixed-effects and random-effects models.
resultsVP/VLBW status was associated with a significant difference in the Health Utilities Index Mark 3 multi-attribute utility score of - 0.06 (95% confidence interval - 0.08, - 0.04) in comparison to birth at term or at normal birthweight; this was not replicated for the Short Form 6D. Impacted functional domains included vision, ambulation, dexterity and cognition. VP/VLBW status was not associated with poorer emotional or social functioning, or increased pain.
conclusionsVP/VLBW status is associated with lower overall health-related quality of life in early adulthood, particularly in terms of physical and cognitive functioning. Further studies that estimate the effects of VP/VLBW status on health-related quality-of-life outcomes in mid and late adulthood are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.