Evidence map›Paper›PMID 36287325›Full record

ReviewAging clinical and experimental research2022

Role of vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group.

Thierry Chevalley, Maria Luisa Brandi, Kevin D Cashman, Etienne Cavalier, Nicholas C Harvey, Stefania Maggi, Cyrus Cooper, Nasser Al-Daghri, Oliver Bock, Olivier Bruyère and 20 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 6 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 6 syntheses or guidelines pooled it, 105 citations in OpenAlex.

  1. The Lebanese GRADE-based vitamin D guidelines: a paradigm for the MENA region.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. [Malnutrition-A central geriatric syndrome].Zeitschrift fur Gerontologie und Geriatrie · 2026
    Review
  18. Foods (Basel, Switzerland) · 2026
    Review
  19. Article
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 20 institutions in 12 countries.

Thierry ChevalleyService of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland. Thierry.chevalley@hcuge.ch.ORCID http://orcid.org/0000-0003-3338-1148
Maria Luisa BrandiMetabolic Bone Diseases Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.
Kevin D CashmanCork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, Cork, Ireland.
Etienne CavalierDepartment of Clinical Chemistry, University of Liege, CHU de Liege, Liege, Belgium.
Nicholas C HarveyMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
Stefania MaggiCNR Aging Branch-IN, Padua, Italy.
Cyrus CooperMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
Nasser Al-DaghriChair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science King Saud University, Riyadh, 11451, Saudi Arabia.
Oliver BockDepartment of Osteoporosis, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Olivier BruyèreDivision of Public Health, Epidemiology and Health Economics, WHO Collaborating Center for Public Health Aspects of Musculo-Skeletal Health and Ageing, University of Liège, Liege, Belgium.
Mario Miguel RosaCentro de Estudos Egas Moniz Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.
Bernard CortetDepartment of Rheumatology, University of Lille, CHU Lille, MABlab ULR 4490, Lille, France.
Alfonso J Cruz-JentoftServicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain.
Antonio CherubiniDipartimento dei percorsi geriatrici della fragilità, Geriatria, Accettazione geriatrica e Centro di ricerca per l'invecchiamentodella continuità di cura e riabilitativi, IRCCS INRCA, Ancona, Italy.
Bess Dawson-HughesJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
Roger FieldingJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
Nicholas FuggleMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
Philippe HalboutInternational Osteoporosis Foundation, Nyon, Switzerland.
John A KanisCentre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK.
Jean-Marc KaufmanDepartment of Endocrinology, Ghent University Hospital, Ghent, Belgium.
Olivier LamyBone Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-3684-2376
Andrea LaslopScientific Office, Federal Office for Safety in Health Care, Austrian Medicines and Medical Devices Agency, Vienna, Austria.
Maria Concepción Prieto YerroSpanish Agency for Medicines and Medical Devices, Madrid, Spain.
Régis RadermeckerDepartment of Clinical Pharmacology Diabetes, Nutrition and Metabolic Disorders, CHU Liege, Liège, Belgium.
Jotheeswaran Amuthavalli ThiyagarajanAgeing and Health Unit, Department of Maternal, Newborn, Child and Adolescent Health & Ageing, WHO HQ, Geneva, Switzerland.
Thierry ThomasDepartment of Rheumatology, North Hospital, CHU Saint-Etienne and INSERM U1059, University of Lyon-University Jean Monnet, Saint-Etienne, France.
Nicola VeroneseGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy.
Marten de WitDepartment of Medical Humanities, Amsterdam University Medical Centre, Amsterdam, The Netherlands.
Jean-Yves ReginsterDepartment of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.
René RizzoliService of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
University of Liège · BEUniversity Hospital Southampton NHS Foundation Trust · GBTufts University · USAustralian Catholic University · AUAustrian Agency for Health and Food Safety · ATGhent University Hospital · BEInstituto Ramón y Cajal de Investigación Sanitaria · ESIstituti di Ricovero e Cura a Carattere Scientifico · ITKing Saud University · SAUniversité Claude Bernard Lyon 1 · FRUniversité de Lille · FRUniversity College Cork · IEUniversity Hospital of Geneva · CHUniversity of Bern · CHUniversity of Florence · ITUniversity of Geneva · CHUniversity of Lausanne · CHUniversity of Lisbon · PTUniversity of Palermo · ITWorld Health Organization · CH

Funding

Medical Research Council G0400491Medical Research Council MC_PC_21000Medical Research Council MC_PC_21001Medical Research Council MC_PC_21003Medical Research Council MC_PC_21022Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1015Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/2Versus Arthritis 21231World Health Organization 001
6 · The paper itself

Abstract

Vitamin D is a key component for optimal growth and for calcium-phosphate homeostasis. Skin photosynthesis is the main source of vitamin D. Limited sun exposure and insufficient dietary vitamin D supply justify vitamin D supplementation in certain age groups. In older adults, recommended doses for vitamin D supplementation vary between 200 and 2000 IU/day, to achieve a goal of circulating 25-hydroxyvitamin D (calcifediol) of at least 50 nmol/L. The target level depends on the population being supplemented, the assessed system, and the outcome. Several recent large randomized trials with oral vitamin D regimens varying between 2000 and 100,000 IU/month and mostly conducted in vitamin D-replete and healthy individuals have failed to detect any efficacy of these approaches for the prevention of fracture and falls. Considering the well-recognized major musculoskeletal disorders associated with severe vitamin D deficiency and taking into account a possible biphasic effects of vitamin D on fracture and fall risks, an European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group convened, carefully reviewed, and analyzed the meta-analyses of randomized controlled trials on the effects of vitamin D on fracture risk, falls or osteoarthritis, and came to the conclusion that 1000 IU daily should be recommended in patients at increased risk of vitamin D deficiency. The group also addressed the identification of patients possibly benefitting from a vitamin D loading dose to achieve early 25-hydroxyvitamin D therapeutic level or from calcifediol administration.

Indexed as

Bone Density Conservation AgentsFractures, BoneOsteoarthritisOsteoporosisVitamin D DeficiencyAgedCalcifediolDietary SupplementsHumansVitamin DVitaminsBone Density Conservation AgentsCalcifediolVitamin DVitaminsFallsFragility fractureOsteoarthritisVitamin D

Identifiers

PMID36287325
PMCPMC9607746
OpenAlexW4307571967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.