A Practical Peptide Synthesis Workflow Using Amino-Li-Resin.

Damilola Caleb Akintayo, Srinivasa Rao Manne, Beatriz G de la Torre, Yongfu Li, Fernando Albericio

Abstract read

In one paragraph

Article in Methods and protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Toward a Green SPPS: The Use of an Innovative Mesoporous pDVB Support for Environmentally Friendly Solvents.Journal of peptide science : an official publication of the European Peptide Society · 2025
Article
Novel Amino-Li Resin for Water-Based Solid-Phase Peptide Synthesis.Methods in molecular biology (Clifton, N.J.) · 2025
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Damilola Caleb AkintayoPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4000, South Africa.ORCID 0000-0003-1742-3571

Srinivasa Rao MannePeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4000, South Africa.ORCID 0000-0002-9837-9789

Beatriz G de la TorreKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.ORCID 0000-0001-8521-9172

Yongfu LiBiotide Core, LLC, 33815 SE Eastgate Circle, Corvallis, OR 97333, USA.

Fernando AlbericioPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4000, South Africa.ORCID 0000-0002-8946-0462

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein we report a practical approach for peptide synthesis using second-generation fibrous polyacrylamide resin (Li-resin, "Li" is coming from the name of its inventor, Yongfu Li). This resin with the corresponding handle was used for solid phase peptide synthesis (SPPS) using a fluorenylmethoxycarbonyl (Fmoc) approach. We reveal that the most appropriate mixing and filtration strategy when using amino-Li-resin in SPPS is via shaking and gravity filtration, instead of mechanical stirring and suction filtration used with other resins. The strategy was demonstrated with the SPPS of H-Tyr-Ile-Ile-Phe-Leu-NH

Indexed as

amino-Li-resingravity filtrationshakingsolid-phase peptide synthesis

Identifiers

PMID36287044

DOI10.3390/mps5050072

PMCPMC9610658

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.