ArticlemSystems2022
Potential Role of Lysine Acetylation in Antibiotic Resistance of Escherichia coli.
Article in mSystems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Proteomic Insights into Antimicrobial Resistance Mechanisms in Human-Associated Bacterial Pathogens.Microbial ecology · 2026Review
- Probiotics Exert Colonization Resistance AgainstMicroorganisms · 2026Article
- Crotonylation driving Streptococcus pneumoniae adaption and virulence.Journal of advanced research · 2026Article
- Genome-centric metagenomes unveiling microbial functional potential in a glacier river in the Mount everest.World journal of microbiology & biotechnology · 2026Article
- Lysine acetylome profiling reveals a dual regulatory role in carbon flux redirection and RNA degradation inhibition inFrontiers in microbiology · 2026Article
- Molecular mechanism of gallium nitrate in inhibiting bacterial biofilm formation through pykF modulation.PloS one · 2026Article
- Antechokinetics, the kinetics of antimicrobial resistance molecules.Frontiers in pharmacology · 2026Review
- Intracellular acetyl phosphate modulatesActa biochimica et biophysica Sinica · 2025Article
- Potential role of lysine acetylation in the stepwise adaptation ofMicrobiology spectrum · 2025Article
- Diurnal oscillations of amino acids dynamically associate with microbiota and resistome in the colon of pigs.Animal microbiome · 2025Article
- The role of universal stress protein Usp1413 in meropenem adaptive resistance and environmental stress responses inCurrent research in microbial sciences · 2025Article
- Based on quorum sensing: reverse effect of traditional Chinese medicine on bacterial drug resistance mechanism.Frontiers in cellular and infection microbiology · 2025Review
- Antimicrobial activity and mechanistic insights of AMP-17 against drug-resistantFrontiers in cellular and infection microbiology · 2025Article
- The Effect of the Lysine Acetylation Modification of ClpP on the Virulence ofMolecules (Basel, Switzerland) · 2024Article
- Acetyl-proteome profiling revealed the role of lysine acetylation in erythromycin resistance ofHeliyon · 2024Article
- Transcriptomic analyses of Vibrio parahaemolyticus under the phenyllactic acid stress.Applied microbiology and biotechnology · 2024Article
- Influence of NMolecules (Basel, Switzerland) · 2024Article
- Bacterial protein acetylation: mechanisms, functions, and methods for study.Frontiers in cellular and infection microbiology · 2024Review
- Acetylomics reveals an extensive acetylation diversity withinmicroLife · 2024Article
- Succinylation modification provides new insights for the treatment of immunocompromised individuals with drug-resistantFrontiers in immunology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotic resistance is increasingly becoming a challenge to public health. The regulation of bacterial metabolism by post-translational modifications (PTMs) has been widely studied. However, the mechanism underlying the regulation of acetylation in bacterial resistance to antibiotics is still unknown. Here, we performed a quantitative analysis of the acetylated proteome of a wild-type (WT) Escherichia coli (E. coli) sensitive strain and ampicillin- (Re-Amp), kanamycin- (Re-Kan), and polymyxin B-resistant (Re-Pol) strains. Based on bioinformatics analysis combined with biochemical validations, we found a common regulatory mechanism between the different resistant strains. Our results showed that protein acetylation negatively regulates bacterial metabolism to regulate antibiotic resistance and positively regulates bacterial motility. Further analyses revealed that key enzymes in various metabolic pathways were differentially acetylated. In particular, pyruvate kinase (PykF), a glycolytic enzyme that regulates bacterial metabolism, and its acetylated form were highly expressed in the three resistant strains and were identified as reversibly acetylated by the deacetylase CobB and the acetyl-transferase PatZ (peptidyl-lysine
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.