Evidence map›Paper›PMID 36286552›Full record

ArticleAntimicrobial agents and chemotherapy2022

Synergistic Effect of the Combination of Deferoxamine and Fluconazole

Lulu An, Jingwen Tan, Yuanyuan Wang, Siyu Liu, Yongyong Li, Lianjuan Yang

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Inhibitory effect of copper chelators on the budding inAntimicrobial agents and chemotherapy · 2025
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  3. Infection and immunity · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lulu AnDepartment of Medical Mycology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Jingwen TanDepartment of Medical Mycology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Yuanyuan WangDepartment of Medical Mycology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Siyu LiuDepartment of Medical Mycology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Yongyong LiInstitute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai, People's Republic of China.
Lianjuan YangDepartment of Medical Mycology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.ORCID 0000-0002-7890-6553
Tongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The opportunistic fungal infections are an increasing threat to humans due to the increasing number of patients with immunodeficiency, in which the most popular fungal pathogen is Candida albicans. Fluconazole (FLC) is the common drug for treating C. albicans infections, but increasing drug resistance has limited its clinical use. Currently, combination therapy is being investigated as a treatment to overcome the resistance of C. albicans. This report investigated the synergistic properties of deferoxamine (DFO) and FLC combination therapy

Indexed as

CandidaFluconazoleAntifungal AgentsCandida albicansCandida glabrataDeferoxamineDrug Resistance, FungalDrug SynergismHumansMicrobial Sensitivity TestsAntifungal AgentsDeferoxamineFluconazoleCandida albicanscutaneous candidiasisdeferoxaminedrug resistancesynergistic effect

Identifiers

PMID36286552
PMCPMC9664841
OpenAlexW4307342672

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.